Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan.

Alpha-band resting-state functional connectivity decreased with age across widespread cortical networks.

• The study utilized MEG recordings from 576 adults aged 18-87 years.
• Alpha band was defined as 8-13 Hz.
• The age-related decrease in alpha-band rs-FC was observed in widespread cortical networks.
• This pattern differed from concurrent changes in oscillatory power, underscoring dissociable contributions.

Delta-, theta-, and gamma-band resting-state functional connectivity increased with age.

• Delta band was defined as 1-4 Hz, theta as 4-8 Hz, and gamma as 40-90 Hz.
• These increases were observed across widespread cortical networks.
• The global delta, theta, and beta-band patterns differed from concurrent changes in oscillatory power.
• The sample consisted of 576 adults aged 18-87 years assessed with MEG resting-state recordings.

Beta-band resting-state functional connectivity followed a non-linear trajectory, peaking in middle age.

• Beta band was defined as 13-30 Hz.
• The non-linear trajectory distinguished beta-band rs-FC from the monotonic patterns observed in other frequency bands.
• The global beta-band pattern differed from concurrent changes in oscillatory power.
• This finding was derived from a lifespan sample of 576 adults aged 18-87 years.

Reduced beta-band resting-state functional connectivity was associated with increased sensorimotor attenuation.

• This association indicates that changes in rs-FC are behaviorally relevant for sensorimotor function.
• Sensorimotor attenuation refers to the reduced perception of self-generated sensory stimuli.
• The finding highlights a link between resting-state brain activity and sensorimotor integration.
• The association was observed in the context of age-related changes in beta-band rs-FC.

Age-related changes in resting-state functional connectivity were dissociable from concurrent changes in oscillatory power.

• The global delta, theta, alpha, and beta-band rs-FC patterns differed from concurrent changes in oscillatory power.
• This dissociation underscores that rs-FC and oscillatory power represent distinct aspects of brain activity.
• The findings were derived from resting-state MEG recordings in 576 adults aged 18-87 years.
• Frequency-specific changes were observed across all classical frequency bands from delta to gamma.

The study investigated resting-state functional connectivity using MEG in a large adult lifespan sample.

• MEG recordings were obtained from 576 adults aged 18-87 years.
• Resting-state functional connectivity was examined across delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz), and gamma (40-90 Hz) frequency bands.
• The study focused on cortical functional connectivity.
• Both global connectivity patterns and their behavioral relevance were examined.