Gut microbiota profiles by LDL-C target achievement in statin-treated patients: A cross-sectional study.

No significant differences in microbial species diversity were found between LDL-C target-achieved and target-not-achieved groups.

• Alpha diversity was assessed using the Chao1 index and Shannon index
• Beta diversity was also compared between the two groups
• Microbial dysbiosis index showed no significant difference between groups
• The LDL-C target-achieved group was defined as LDL-C < 70 mg/dL (n=57) and target-not-achieved as LDL-C ≥ 70 mg/dL (n=68)

The LDL-C target-achieved group exhibited a distinct microbial community structure with decreased abundances of specific genera.

• Decreased abundances were found at the genus level in the LDL-C target-achieved group
• Specific genera with reduced abundance included Barnesiella, Coprococcus 1, Flavonifractor, Odoribacter, and Coprobacter
• Despite the distinct community structure, overall beta diversity was not significantly different between groups

The LDL-C target-achieved group was associated with a significant reduction in short-chain fatty acid-producing bacteria.

• Short-chain fatty acid-producing taxa with reduced abundance included Barnesiella, Coprococcus 1, Flavonifractor, and Odoribacter
• These taxa are recognized as short-chain fatty acid-producing bacteria
• Coprobacter was also decreased but was not listed among the short-chain fatty acid-producing bacteria in the abstract

The study population consisted of 125 statin-treated chronic disease patients with high comorbidity burden.

• Total of 125 patients were recruited (77 males and 48 females)
• Comorbidities included diabetes mellitus (87%), hypertension (74%), and chronic kidney disease (48%)
• Fecal samples were analyzed using Illumina sequencing of the 16S ribosomal RNA gene
• Patients were divided into two groups: LDL-C < 70 mg/dL (n=57) and LDL-C ≥ 70 mg/dL (n=68)