Cardiovascular

Health outcomes of U.S. active component service members working in high risk occupations for blast overpressure exposure: a retrospective cohort study.

TL;DR

Adjusted incidence rates of TBI and NIHI were higher among service members in occupations at high risk for blast overpressure exposure than among those who had never worked in such occupations, and increasing time in the cohort was associated with a greater increase in migraine headache incidence among high-risk BOP occupation members.

Key Findings

Active component service members in high-risk blast overpressure occupations had a higher overall incidence of traumatic brain injury than those in low-risk occupations.

  • Overall incidence of TBI was 243.8 per 10,000 person-years in the high-risk occupational cohort.
  • Overall incidence of TBI was 140.9 per 10,000 person-years in the low-risk occupational cohort.
  • After adjusting for demographic and military characteristics, the adjusted incidence rate ratio (aIRR) for TBI was 1.43 (95% CI 1.42, 1.44).
  • The high-risk cohort comprised 831,050 service members; the low-risk cohort comprised 2,229,594 service members.
  • The study included active component service members from the U.S. Army, Air Force, and Marine Corps.

Active component service members in high-risk blast overpressure occupations had a higher overall incidence of noise-induced hearing injury than those in low-risk occupations.

  • Incidence of NIHI was 342.7 per 10,000 person-years in the high-risk occupational cohort.
  • Incidence of NIHI was 218.1 per 10,000 person-years in the low-risk occupational cohort.
  • After adjustment, the aIRR for NIHI was 1.39 (95% CI 1.38, 1.40).
  • NIHI was one of six health outcomes examined alongside TBI, insomnia, migraine headache, depressive or anxiety disorders, and essential hypertension.

Increasing time since entering the cohort was associated with a greater increase in migraine headache incidence among service members in high-risk BOP occupations compared with those in low-risk occupations.

  • The association between cohort membership and migraine headache incidence grew over time, suggesting a cumulative or latent effect of BOP exposure.
  • This temporal pattern was specific to migraine headache and was not described as the primary finding for other health outcomes examined.
  • This finding was highlighted as one of the two main conclusions in the abstract.

The distribution of disease burden categories from 2024 health care encounters was similar between the high-risk and low-risk BOP occupational cohorts despite differences in specific incidence rates.

  • Overall disease burden category distribution was assessed using 2024 health care encounter data.
  • Despite higher adjusted IRs for TBI and NIHI in the high-risk cohort, the overall distribution of disease burden was comparable between groups.
  • This finding suggests that while specific conditions were more incident in high-risk occupations, the aggregate health burden as measured by encounter data did not differ substantially between cohorts.

This retrospective cohort study examined incidence of six health outcomes among active component service members in occupations at high versus low risk for blast overpressure exposure.

  • The six outcomes examined were: traumatic brain injury (TBI), insomnia, migraine headache, depressive or anxiety disorders, noise-induced hearing injury (NIHI), and essential hypertension.
  • Only first-time diagnoses were counted, measuring incidence rather than prevalence.
  • The study included service members from the U.S. Army, Air Force, and Marine Corps.
  • Incidence rates were adjusted for demographic and military characteristics to produce adjusted IRRs.
  • BOP exposure occurs during both deployment and training activities.

What This Means

This research studied the health of over three million active-duty U.S. military service members, comparing those who worked in jobs with high risk of exposure to blast overpressure (such as from explosions, artillery, or heavy weapons) to those who did not. The study tracked new diagnoses of six health conditions: traumatic brain injury, insomnia, migraine headache, depression or anxiety, noise-induced hearing injury, and high blood pressure. The researchers found that service members in high-risk blast exposure jobs developed traumatic brain injury and noise-induced hearing injury at significantly higher rates — about 43% and 39% higher, respectively — even after accounting for differences in age, sex, and other characteristics between the groups. The study also found that the longer service members spent in high-risk blast-exposure occupations, the greater the gap in migraine headache rates became between those in high-risk versus low-risk jobs. This suggests that the effects of repeated blast exposure on migraine risk may build up over time rather than appearing all at once. Interestingly, despite these specific differences in certain diagnoses, the overall health care burden — as measured by 2024 medical visits — was similar between the two groups. This research suggests that working in military occupations with frequent blast exposure carries meaningful long-term health risks, particularly for brain injury, hearing loss, and migraines. The findings point to the importance of better protecting service members from blast hazards during both training and deployment, and of monitoring the health of those in high-risk roles over the long term to catch problems early.

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Citation

Gildehaus J, Skellington C, Baker Miller S, Nieh C, Stahlman S. (2026). Health outcomes of U.S. active component service members working in high risk occupations for blast overpressure exposure: a retrospective cohort study.. MSMR. https://pubmed.ncbi.nlm.nih.gov/42865728/