Mental Health

Health, stress, and resilience among Latino immigrant families (SER Familia): A protocol to evaluate a multi-level, family-based community prevention program.

TL;DR

This paper describes the protocol for SER Familia, a community-based intervention using a Syndemic Prevention Framework to address acculturative stress and promote resilience among Latino immigrant families through a randomized trial of 380 immigrant parent-youth dyads.

Key Findings

Acculturative stress is identified as the strongest social driver of a syndemic of substance use, intimate partner violence, HIV, and mental health conditions in Latino immigrant communities.

  • The paper frames these conditions as a 'syndemic' — conditions that cluster in marginalized communities.
  • Acculturative stress refers to the stress associated with adapting to a new culture and context.
  • Both adults and youth are described as experiencing health declines related to acculturative stress.
  • The authors note there are 'limited interventions addressing acculturative stress and resilience in this population.'

The SER Familia trial is enrolling a total of 380 immigrant parent-youth dyads who are being randomized to the intervention or a delayed intervention condition.

  • One parent and one child from each family constitute a dyad, making the sample 380 families.
  • Participants are randomized to either the SER Familia program or a delayed intervention (waitlist control) condition.
  • The intervention consists of six sessions delivered with families and groups.
  • The intervention is delivered by community health workers.

The SER Familia intervention targets acculturative stress reduction and resilience enhancement through three specific resilience components: coping, ethnic pride, and social support.

  • Community health workers work with families to improve family health by reducing acculturative stress and enhancing resilience.
  • The program uses a Syndemic Prevention Framework as its theoretical basis.
  • The intervention is community-based and culturally specific.
  • The program involves both family-level and group-level session components across six sessions.

The study uses four data collection timepoints to evaluate intervention effectiveness, including a pre-intervention baseline and follow-ups at 3, 6, and 12 months.

  • Both standardized and culturally specific measures are administered at each timepoint.
  • Data collection uses a mixed-methods approach.
  • Aim 1 is to determine effectiveness in preventing or reducing syndemic outcomes.
  • Aim 2 is to describe the mechanisms of change of the intervention.

The study protocol is designed with implications for health promotion and disease prevention interventions not only for Latinos but also for other immigrant populations.

  • Latinos are identified as the largest racial and ethnic group in the US.
  • The protocol targets both adults (parents) and youth (children) within family units.
  • The Syndemic Prevention Framework is positioned as applicable to other marginalized immigrant communities.
  • The intervention addresses multiple co-occurring health conditions simultaneously rather than single conditions in isolation.

What This Means

This research describes the design of a study called SER Familia, which tests a community health program for Latino immigrant families in the United States. The program is built around the idea that the stress of adapting to a new country — called acculturative stress — is a major driver of multiple interrelated health problems, including substance use, domestic violence, HIV risk, and mental health issues. These problems tend to cluster together in immigrant communities, a phenomenon researchers call a 'syndemic.' The program works with families over six sessions, led by community health workers, to reduce this stress and build resilience through improved coping skills, cultural pride, and social support networks. The trial is enrolling 380 families, with one parent and one child from each family participating. Half the families receive the program right away, while the other half are placed on a waitlist — a common research design that allows scientists to compare outcomes between the two groups. Families complete surveys and other assessments four times: before the program begins, and at 3, 6, and 12 months afterward. This allows researchers to track whether the program reduces health problems over time and to understand how and why it works. This research suggests that addressing the root stresses of immigration — rather than tackling each health problem separately — could be an effective and culturally grounded approach for improving the health of Latino immigrants and potentially other immigrant communities. By training community health workers from within these communities to deliver the program, the approach also aims to make it more accessible and sustainable for populations that are often underserved by traditional healthcare systems.

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Citation

Gonzalez-Guarda R, McCabe B, Stafford A, Nagy G, Felsman I, Solorzano R, et al.. (2026). Health, stress, and resilience among Latino immigrant families (SER Familia): A protocol to evaluate a multi-level, family-based community prevention program.. Contemporary clinical trials. https://doi.org/10.1016/j.cct.2026.108315