Cardiovascular

Hierarchical Management of Chronic Infectious Diabetic Foot Wounds During the COVID-19 Pandemic: A Single-Center Retrospective Observational Study.

TL;DR

A hierarchical management strategy for diabetic foot patients during the COVID-19 pandemic allowed essential care to be maintained with no observed COVID-19 cases in a small retrospective cohort, though hospital attendance was markedly reduced compared to the prior year.

Key Findings

Hospital attendance for diabetic foot patients during the COVID-19 pandemic period was markedly reduced compared to the corresponding period in 2019.

  • A total of 12 patients were treated during the study period (January 23 to March 27, 2020)
  • Attendance reduction compared to the corresponding period in 2019 was statistically significant (P < 0.0001)
  • The study was conducted at a single center in a retrospective observational design

The majority of patients treated during the pandemic period had severe diabetic foot lesions.

  • 58% of patients had Wagner grade 4-5 lesions, representing the most severe categories of diabetic foot classification
  • Most patients were older adults with multiple comorbidities
  • Demographic characteristics, comorbidities, Wagner classification, treatment strategies, and clinical outcomes were collected from electronic medical records

Surgical treatment was required for the majority of patients treated during the study period.

  • Surgical treatment was performed in 8 of 12 patients (approximately 67%)
  • The mean hospital stay was 27.5 days ± 20.2 days
  • The wide standard deviation indicates considerable variability in length of hospitalization among patients

No patients developed laboratory-confirmed COVID-19 during hospitalization or follow-up.

  • Zero cases of COVID-19 were confirmed among the 12 patients in the cohort
  • This finding was observed in the context of the hierarchical management strategy adopted at the institution
  • The authors note this was a small retrospective cohort and further studies involving larger populations are needed to evaluate effectiveness and generalizability

One patient died during the study period from infectious shock secondary to diabetic foot infection, unrelated to COVID-19.

  • The single death was attributed to infectious shock secondary to diabetic foot infection
  • The death was explicitly reported as unrelated to COVID-19
  • This represents a mortality rate of approximately 8.3% (1 of 12 patients) in this small cohort

Patients with diabetic foot were identified as potentially more vulnerable during infectious disease outbreaks due to their clinical profile.

  • Vulnerability factors identified included advanced age, diabetes, multiple comorbidities, and chronic wounds requiring ongoing medical care
  • Diabetic foot patients often require repeated outpatient visits, hospitalization, and surgical intervention, making continuous wound care particularly challenging during the pandemic
  • These characteristics were discussed as reasons why maintaining care continuity was important for this population

What This Means

This research describes how a single hospital in China managed patients with diabetic foot wounds during the early months of the COVID-19 pandemic (January to March 2020). Diabetic foot is a serious complication of diabetes where wounds on the feet become chronic, infected, and difficult to heal, often requiring repeated hospital visits and sometimes surgery. The study found that far fewer patients came in for care during the pandemic compared to the same period in the previous year, which raises concerns about untreated cases in the broader community. Among the 12 patients who did receive care, most had severe wounds and multiple other health problems, and about two-thirds needed surgery, with an average hospital stay of nearly four weeks. The hospital implemented what the authors call a 'hierarchical management strategy' to continue providing essential diabetic foot care while minimizing COVID-19 risk, and none of the 12 patients contracted COVID-19 during their hospitalization or follow-up period. One patient died from severe infection related to their diabetic foot condition, not from COVID-19. This research suggests that structured management approaches may help maintain care for vulnerable patients with complex chronic conditions during infectious disease outbreaks, though the very small number of patients (only 12) means firm conclusions cannot be drawn. The practical implication of this research is that people with diabetic foot wounds are particularly at risk during public health emergencies because their conditions require ongoing, frequent medical attention that can be disrupted by pandemic conditions. The sharp drop in patient attendance observed in this study suggests that many patients with diabetic foot may have avoided seeking care during the pandemic, potentially leading to worsening of their conditions. The authors call for larger studies to properly evaluate whether hierarchical management strategies can reliably protect this vulnerable population while keeping them safe from additional infections.

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Citation

Li J, Zhou H, Jin Q, Lu H. (2026). Hierarchical Management of Chronic Infectious Diabetic Foot Wounds During the COVID-19 Pandemic: A Single-Center Retrospective Observational Study.. Journal of visualized experiments : JoVE. https://doi.org/10.3791/71893