Higher HbA1c-Hemoglobin Ratio Was Associated With Poor Outcome in Endovascular Thrombectomy Patients.

Higher HbA1c-to-hemoglobin ratio (HHR) independently predicted worse functional recovery at 90 days in patients undergoing endovascular thrombectomy.

• Multivariate logistic regression yielded an adjusted OR of 10.484 (95% CI: 4.581–23.990; p = 0.001) for higher HHR levels upon hospital admission.
• Poor clinical outcomes were defined as modified Rankin Scale scores of 3–6 at 90-day follow-up.
• The study enrolled 353 participants with an average age of 70.5 years (SD 12.2); 218 were male.
• Of the 353 participants, 181 (51.3%) showed adverse clinical results at 90 days.

Restricted cubic spline analysis confirmed a nonlinear, dose-dependent relationship between HHR values and the likelihood of poor prognosis.

• The nonlinearity p-value was 0.001, indicating a statistically significant nonlinear association.
• The relationship was described as 'dose-dependent,' suggesting increasing HHR corresponds to increasing risk of poor outcome.
• This analysis was used as additional investigation beyond the primary multivariate logistic regression.

Continuous HHR measurements demonstrated strong discriminatory capability for predicting poor 90-day outcomes.

• The area under the receiver operating characteristic curve (AUC) for HHR was 0.760 (95% CI: 0.710–0.810).
• HHR was assessed as a continuous variable in the predictive framework.
• This AUC value was described as reflecting 'strong discriminatory capability.'

The study was a retrospective evaluation of patients undergoing endovascular treatment (EVT) at a single center over approximately two years.

• Patients were enrolled from Nanjing First Hospital from April 2022 to June 2024.
• HHR was calculated by dividing HbA1c levels by hemoglobin values measured upon hospital admission.
• A total of 353 participants were included in the analysis.
• Multivariate logistic regression was the primary statistical method for examining the association between HHR and functional outcomes.