Cardiovascular

Incremental Value of Cardiovascular CT in Neonates and Infants with Congenital Heart Disease: An Integrated Multimodality Imaging Approach.

TL;DR

In a highly selected cohort of neonates and infants with CHD in whom expert TTE leaves a clinically relevant question unresolved, CCT may provide incremental information, particularly regarding coronary and extracardiac vascular anatomy, supporting a targeted multimodality strategy in which CCT complements echocardiography.

Key Findings

CCT provided additional anatomic characterization beyond TTE in just over half of the infants studied, mostly involving extracardiac vascular structures.

  • Additional anatomic characterization was provided in 14/26 patients (53.8%).
  • The primary endpoint was the incremental anatomic information provided by CCT beyond TTE.
  • The additional information predominantly involved extracardiac vascular structures.
  • The study was a retrospective review of 26 consecutive patients aged <1 year with CHD, 14 (53.8%) of whom were neonates.

CCT findings were discordant with TTE regarding the unresolved target anatomy in nearly half of patients.

  • Discordance occurred in 12/26 patients (46.2%).
  • Patients were referred after multidisciplinary review because TTE was inconclusive or additional anatomic definition was needed for surgical planning.

The most frequent reasons for requesting CCT were assessment of coronary anatomy, pulmonary veins, pulmonary arteries/MAPCAs, and aortic arch.

  • Coronary anatomy: 9/26 (38.5%).
  • Pulmonary veins: 4/26 (15.4%).
  • Pulmonary arteries/MAPCAs: 4/26 (15.4%).
  • Aortic arch: 3/26 (11.5%).

Against operative findings, CCT was more accurate than TTE for extracardiac and coronary abnormalities, while both were highly accurate for intracardiac abnormalities.

  • TTE accuracy was 96.2% for intracardiac, 41.2% for extracardiac, and 11.1% for coronary abnormalities.
  • CCT accuracy was 100% for intracardiac, 94.1% for extracardiac, and 100% for coronary abnormalities.
  • Operative findings served as the reference standard.

CCT directly informed the surgical approach in two patients with total anomalous pulmonary venous drainage.

  • The abstract reports this for two patients with total anomalous pulmonary venous drainage (TAPVD).

All CCT examinations had image quality sufficient to answer the clinical question, and no contrast-related adverse events occurred.

  • Sufficient image quality was achieved in all examinations for the specific clinical question.
  • No contrast-related adverse events were observed.
  • Procedural safety, contrast administration, and acquisition characteristics were secondary analyses.

Radiation exposure from CCT in this cohort had a median estimated effective dose of 3.62 mSv.

  • Median estimated effective dose was 3.62 mSv (IQR, 1.94-6.06).

The authors conclude that CCT may complement echocardiography in a targeted, question-driven multimodality strategy for surgical planning in selected infants with CHD.

  • The cohort was described as highly selected, with expert TTE leaving a clinically relevant question unresolved.
  • CCT may provide incremental information particularly regarding coronary and extracardiac vascular anatomy.
  • CCT use should be tailored to the anatomic question relevant to surgical planning.

What This Means

This study looked back at 26 babies under one year old with congenital heart disease (half were newborns) who had a cardiac CT scan after ultrasound of the heart (echocardiography) could not fully answer a question the surgical team had. Echocardiography is the standard first test, so CT was used only in selected cases, most often to look at the heart's own blood vessels (coronary arteries), the veins from the lungs, the aortic arch, or the lung arteries. CT added useful anatomical information in about half of the babies (14 of 26), mostly about blood vessels outside the heart, and its findings differed from the ultrasound in 12 of 26. When compared with what surgeons actually found, CT was correct far more often than ultrasound for vessels outside the heart (about 94% vs 41%) and for coronary arteries (100% vs 11%), while both did well for structures inside the heart. In two babies with abnormal lung vein connections, CT directly shaped the surgical approach. All scans were good enough to answer the question, no contrast-related reactions occurred, and the median estimated radiation dose was 3.62 mSv. This research suggests that CT may be a helpful add-on to echocardiography when specific questions remain unanswered before heart surgery in infants. The study was small, retrospective, and involved a carefully selected group, so the findings do not show that all infants with heart disease need CT, and radiation exposure remains a consideration.

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Citation

Pomiato E, Pozza A, Cattapan I, Cavaliere A, Reffo E, Avesani M, et al.. (2026). Incremental Value of Cardiovascular CT in Neonates and Infants with Congenital Heart Disease: An Integrated Multimodality Imaging Approach.. Medical sciences (Basel, Switzerland). https://doi.org/10.3390/medsci14060687