Inverse association of insulin-like growth factor binding protein 1 with epicardial and intrathoracic adiposity in older adults: The Longenity study.

Higher serum IGFBP-1 levels were statistically significantly associated with lower epicardial adipose tissue (EAT) and intrathoracic adipose tissue (IAT) in the overall study sample.

• Study included n=102 participants from the LonGenity parent study at the Albert Einstein Institute of Aging, Bronx NY
• Participants were Ashkenazi Jewish offspring of parents with exceptional longevity (OPEL) or usual survival (OPUS)
• EAT and IAT were measured via non-contrast electrocardiogram-gated computed tomography (CT) for fat volume quantification
• Multiple linear regression models were adjusted for demographic, clinical, and laboratory factors including age, BMI, HDL cholesterol, and cardiometabolic factors

The inverse association between IGFBP-1 and both EAT and IAT was particularly significant among offspring of parents with exceptional longevity (OPEL).

• In OPEL participants, the inverse relationship between IGFBP-1 and EAT/IAT remained statistically significant after full adjustment
• Among OPUS participants, point estimates for the associations were directionally similar (inverse) but did not reach statistical significance
• This suggests a potential differential effect of IGFBP-1 on adiposity based on parental longevity status

The inverse association of IGFBP-1 with EAT and IAT remained significant after adjusting for multiple confounders.

• Adjustment variables included age, body mass index, high-density lipoprotein cholesterol, and cardiometabolic factors
• Cross-sectional study design was used for these analyses
• The association persisted despite comprehensive covariate adjustment, suggesting an independent relationship

The study investigated a population specifically enriched for healthy aging genetics through the LonGenity study design.

• The LonGenity study was designed to investigate healthy aging in Ashkenazi Jewish individuals
• Two groups were compared: OPEL (offspring of parents with exceptional longevity) vs. OPUS (offspring of parents with usual survival)
• The study was conducted at the Albert Einstein Institute of Aging, Bronx NY
• Higher serum IGFBP-1 is known to be associated with insulin sensitivity and reduced risk of obesity, diabetes, and atherosclerosis

IGFBP-1 is proposed as a novel biomarker for visceral adiposity and cardiometabolic risk stratification in older adults.

• Epicardial and intrathoracic adipose tissue are established markers associated with increased atherosclerosis
• The study was cross-sectional, and authors call for future studies to explore IGFBP-1's role in cardiovascular aging
• Prior to this study, whether there was an inverse association of IGFBP-1 with EAT and IAT was unknown