Investigating the Effect of Synbiotic and SperiGen Supplementations on Spermatogram in Idiopathic Oligoasthenoteratozoospermia: A Double-Blinded Randomized Clinical Trial.

Combination of Synbiotic and SperiGen significantly increased average change in sperm progressive motility compared to SperiGen and placebo.

• p = 0.001 for between-group comparison of progressive motility change
• 73 patients with idiopathic oligoasthenoteratozoospermia (iOAT) were randomized into two groups
• Treatment duration was 3 months
• One group received SperiGen plus placebo; the other received SperiGen plus 500 mg Synbiotic (FamiLact) daily

Combination of Synbiotic and SperiGen significantly improved DNA fragmentation compared to SperiGen and placebo.

• p = 0.001 for between-group comparison of DNA fragmentation change
• DNA fragmentation is associated with ROS-induced damage to sperm DNA
• Both groups received SperiGen as an antioxidant agent throughout the trial

Combination of Synbiotic and SperiGen significantly reduced levels of non-motile sperm compared to SperiGen and placebo.

• p = 0.018 for between-group comparison of non-motile sperm levels
• This was one of three semen parameters that showed significant between-group differences

Within-group analysis showed that all semen parameters were significantly improved in both treatment groups, with one exception.

• The exception was non-progressive motility in the SperiGen and placebo group, which did not reach significance
• Within-group improvements were observed in both the Synbiotic plus SperiGen group and the SperiGen plus placebo group
• Parameters assessed included sperm concentration, progressive motility, non-progressive motility, non-motile sperm, and DNA fragmentation

The trial was a double-blind randomized clinical trial conducted on infertile males with idiopathic oligoasthenoteratozoospermia (iOAT).

• 73 patients with iOAT were blindly randomized into two groups
• One group received SperiGen plus placebo; the other received SperiGen plus 500 mg Synbiotic (FamiLact) daily
• Semen parameters were measured before and after the 3-month intervention
• Registered as IRCT20190810044500N6, registration date 2020-09-05

Antioxidants are proposed to scavenge reactive oxygen species (ROS) that reduce sperm motility, cause DNA damage, and lead to apoptosis in sperm cells.

• Male infertility is influenced by quantitative and qualitative impairments in spermatogenesis
• SperiGen is described as a multivitamin-mineral supplement for men helping to improve male fertility used as an antioxidant agent
• Synbiotic (FamiLact) was administered at 500 mg daily as the probiotic/prebiotic component