TL;DR
Latent profile analysis identified three distinct profiles of medication safety engagement among older adults with cardiometabolic multimorbidity—'passive participation' (22.47%), 'moderate participation' (52.53%), and 'active participation' (25.0%)—with occupational status, marital status, medical payment method, daily medication type, and treatment burden as significant independent influencing factors.
Key Findings
Results
Latent profile analysis identified three distinct profiles of engagement in medication safety among older adults with cardiometabolic multimorbidity.
The three profiles were labeled 'passive participation,' 'moderate participation,' and 'active participation.'
'Passive participation' comprised 22.47% of the sample.
'Moderate participation' was the largest group at 52.53% of the sample.
'Active participation' comprised 25.0% of the sample.
The study sample consisted of 316 older adult inpatients with cardiometabolic multimorbidity at a class III hospital in Jiangsu, China.
Results
Occupational status was a significant independent factor distinguishing among medication safety engagement profiles.
Identified through multivariate logistic regression analysis.
Statistical significance was reported at p<0.05.
Occupational status was one of five significant independent factors identified.
Results
Marital status was a significant independent factor distinguishing among medication safety engagement profiles.
Identified through multivariate logistic regression analysis.
Statistical significance was reported at p<0.05.
Marital status was one of five significant independent factors identified.
Results
Medical payment method was a significant independent factor distinguishing among medication safety engagement profiles.
Identified through multivariate logistic regression analysis.
Statistical significance was reported at p<0.05.
Medical payment method was one of five significant independent factors identified.
Results
Daily medication type was a significant independent factor distinguishing among medication safety engagement profiles.
Identified through multivariate logistic regression analysis.
Statistical significance was reported at p<0.05.
Daily medication type was one of five significant independent factors identified.
Results
Treatment burden was a significant independent factor distinguishing among medication safety engagement profiles.
Identified through multivariate logistic regression analysis.
Treatment burden was measured using the Multimorbidity Treatment Burden Questionnaire.
Statistical significance was reported at p<0.05.
Treatment burden was one of five significant independent factors identified.
Results
The study confirmed significant heterogeneity in medication safety engagement among older adults with cardiometabolic multimorbidity.
A cross-sectional design was used, conducted at a class III hospital in Jiangsu, China.
Participants completed the Inpatients' Involvement in Medication Safety Scale.
The sample included 316 older adult inpatients with cardiometabolic multimorbidity.
Both latent profile analysis and multivariate regression analyses were employed to identify subgroups and associated factors.
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Citation
Liu C, Chen J, Jin R, Li J, Cui M, Wang F, et al.. (2026). Latent profile analysis and influencing factors of engagement in medication safety among older adults with cardiometabolic multimorbidity: a cross-sectional study.. BMJ open. https://doi.org/10.1136/bmjopen-2025-102627
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