Cardiovascular

Life's Essential 8 score and arterial stiffness in patients with type 2 diabetes.

TL;DR

Attaining a superior long-term cardiovascular health status, as measured by cumulative Life's Essential 8 score, is related to a reduced risk of increased arterial stiffness in patients with type 2 diabetes.

Key Findings

Over a median follow-up of 9.76 years, 1,375 cases of increased arterial stiffness (iAS) were identified among 2,685 patients with type 2 diabetes.

  • iAS was defined as a brachial-ankle pulse wave velocity ≥ 1800 cm/s
  • Patients were enrolled in a cohort study and divided into four groups based on quartiles of cumulative exposure of LE8 (cum-LE8) score
  • Median follow-up duration was 9.76 years

The incidence rate of iAS decreased progressively from the lowest to the highest quartile of cumulative LE8 score.

  • Quartile 1 incidence rate: 71.02 (95% CI: 64.24–78.52) per 1000 person-years
  • Quartile 2 incidence rate: 67.68 (95% CI: 61.13–74.94) per 1000 person-years
  • Quartile 3 incidence rate: 56.05 (95% CI: 50.28–62.47) per 1000 person-years
  • Quartile 4 incidence rate: 50.47 (95% CI: 45.05–56.53) per 1000 person-years

Higher cumulative LE8 score quartiles were associated with significantly lower hazard ratios for iAS compared to the lowest quartile.

  • Quartile 2 vs. Quartile 1: HR 0.69 (95% CI: 0.59–0.80)
  • Quartile 3 vs. Quartile 1: HR 0.41 (95% CI: 0.35–0.49)
  • Quartile 4 vs. Quartile 1: HR 0.15 (95% CI: 0.12–0.18)
  • Cox proportional hazards regression model was used to derive these hazard ratios

The cumulative incidence of iAS was highest in quartile 1 and gradually decreased from quartile 1 to quartile 4.

  • Kaplan-Meier method was used to determine cumulative incidence of iAS
  • Log-rank test was used to evaluate differences among groups
  • Log-rank P < 0.01 for differences across all four quartile groups

What This Means

This research suggests that maintaining better overall cardiovascular health over the long term is linked to a substantially lower risk of developing arterial stiffness — a hardening of the arteries — in people with type 2 diabetes. The study tracked 2,685 diabetes patients for nearly 10 years, measuring their cardiovascular health using the American Heart Association's 'Life's Essential 8' (LE8) scoring system, which combines factors like diet, physical activity, sleep, body weight, blood pressure, blood sugar, and cholesterol. Patients who maintained higher LE8 scores over time had far fewer cases of arterial stiffness than those with lower scores. The difference was striking: compared to those with the lowest cardiovascular health scores, people in the highest scoring group had an 85% lower risk of developing arterial stiffness (hazard ratio of 0.15). Even those in the second and third quartiles had 31% and 59% lower risks, respectively. This suggests a strong, graded relationship — the better someone's overall cardiovascular health profile, the more protected they appeared to be against arterial stiffness. Arterial stiffness is a known risk factor for heart disease and stroke, and people with type 2 diabetes are already at elevated cardiovascular risk. This research suggests that comprehensive, sustained attention to multiple aspects of cardiovascular health — rather than any single factor alone — may be particularly important for reducing arterial stiffness progression in this population. The findings highlight the potential value of the LE8 framework as a way to assess and track long-term cardiovascular health in people living with type 2 diabetes.

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Citation

Li K, Wu X, Qi Q, Hillmeister P, Buschmann I, Wu S, et al.. (2026). Life's Essential 8 score and arterial stiffness in patients with type 2 diabetes.. Archives of endocrinology and metabolism. https://doi.org/10.20945/2359-4292-2026-0117