Light physical activity and sedentary time are associated with multiple comorbid conditions in patients with peripheral artery disease.

Sedentary behavior time was positively associated with multiple comorbid conditions in patients with PAD after adjustments.

• The association between sedentary behavior and multiple comorbid conditions was statistically significant (β = 0.280; p = 0.012).
• Adjustments were made for sex, age, ankle-brachial index, total walking distance, body mass index, and moderate-vigorous physical activity.
• The study used a cross-sectional design with 179 patients with PAD and claudication symptoms.
• Accelerometers were worn for seven consecutive days to measure sedentary behavior time.

Light physical activity time was negatively associated with multiple comorbid conditions in patients with PAD after adjustments.

• The association between light physical activity and multiple comorbid conditions was statistically significant (β = -0.209; p = 0.015).
• Adjustments were made for sex, age, ankle-brachial index, total walking distance, body mass index, and moderate-vigorous physical activity.
• Light physical activity was measured via accelerometer worn for seven consecutive days.
• The negative beta coefficient indicates that higher light physical activity time was associated with fewer comorbid conditions.

Moderate-vigorous physical activity was not significantly associated with multiple comorbid conditions in patients with PAD.

• The association between moderate-vigorous physical activity and multiple comorbid conditions was not statistically significant (p > 0.05).
• This finding contrasts with the significant associations found for both sedentary behavior and light physical activity.
• Moderate-vigorous physical activity was included as a covariate in adjusted models for the other activity behaviors.

The study sample consisted of 179 patients with PAD and claudication symptoms with a mean ankle-brachial index indicating significant arterial disease.

• Participants had a mean age of 66 ± 9 years and 62.6% were male.
• All participants had an ankle-brachial index < 0.90 in at least one limb, with a mean ankle-brachial index of 0.58 ± 0.16.
• Outcome measures included chronic disease count (multiple comorbid conditions), sociodemographic information, body mass index, and total walking distance via six-minute walk test.
• The study used a cross-sectional design with crude and adjusted linear regression models.