Long-term health-related quality of life and lifestyle behavior of patients with acute myeloid leukemia.

Long-term AML survivors exhibited clinically relevant impairments in physical functioning compared to the general population.

• 225 AML survivors were enrolled from 24 centers across 6 countries
• Median time since diagnosis was 8.8 years (IQR 6.4-11.9)
• Median age was 58.9 years (IQR 49.0-67.0)
• SF-36 physical functioning difference: Δ = -8.09, P < .001
• SF-36 role physical scale difference: Δ = -11.09, P < .001
• Physical component summary score difference: Δ = -3.94, P < .001

Survivors treated with allogeneic stem cell transplantation (alloSCT) reported worse HRQoL profiles compared to those treated with autologous SCT or chemotherapy only.

• HRQoL was assessed using both the SF-36 and EORTC QLQ-C30 questionnaires
• Three treatment subgroups were compared: alloSCT, autoSCT, and chemotherapy only
• AlloSCT survivors showed the worst HRQoL profiles among the treatment groups

Comorbidities were highly prevalent among long-term AML survivors, affecting 88.5% of the study population.

• Comorbidities were measured with an adapted version of the validated self-administered comorbidity questionnaire
• 88.5% of survivors reported at least one comorbidity
• The most frequent comorbidities were impaired vision, back pain, and arthrosis/arthritis

A substantial proportion of long-term AML survivors had unhealthy lifestyle behaviors across multiple domains.

• 66.2% of AML survivors were physically inactive
• 80.2% did not meet dietary recommendations
• 55.3% were overweight or obese
• Lifestyle factors assessed included physical activity, diet, smoking, alcohol consumption, and body mass index

Physical inactivity was the only independent factor associated with worse HRQoL in multivariate analysis.

• Multivariate analysis identified physical inactivity as the sole independent predictor of worse HRQoL
• β = -6.3, P < .001
• Other lifestyle and clinical variables were included in the multivariate model