Long-Term IGF-1 Maintenance in the Upper-Normal Range Has Beneficial Effect on Low-Grade Inflammation Marker in Adults with Growth Hormone Deficiency.

Long-term maintenance of IGF-1 SDS in the upper-normal range was associated with significantly lower hs-CRP levels compared to the lower-normal range.

• Median hs-CRP was 0.8 (25-75% range: 0.6-1.1) in the upper-normal IGF-1 SDS group versus 1.8 (25-75% range: 0.8-4.6) in the lower-normal group.
• The difference was statistically significant (p = 0.005).
• A negative correlation was identified between hs-CRP and the 5-year mean IGF-1 SDS.
• The study involved 31 patients with AGHD receiving GHRT with daily GH for more than 5 years.

Long-term maintenance of upper-normal IGF-1 SDS was more common in men than in women.

• Male sex was identified as a characteristic associated with long-term maintenance of upper-normal IGF-1 SDS.
• The higher proportion of male patients in the upper-normal IGF-1 SDS group was a confounding factor in analyses of body composition.
• The association between upper-normal IGF-1 SDS range and lower body fat percentage lost significance after adjusting for sex.

Patients with tumor-related AGHD had a lower 5-year mean IGF-1 SDS compared to other etiologies.

• The etiology of AGHD (tumor-related vs. other) was associated with differences in long-term IGF-1 SDS levels.
• Patients with tumor-related AGHD had a lower 5-year mean IGF-1 SDS.
• This finding emerged from cross-sectional analysis of 31 patients with a 2-year mean IGF-1 SDS ranging between -2 and +2.

Longer duration of GHRT was associated with maintenance of IGF-1 SDS in the upper-normal range.

• Patients with a longer duration of GHRT were more likely to maintain upper-normal IGF-1 SDS.
• All patients had been receiving GHRT for more than 5 years at the time of the study.
• Duration of GHRT was one of the clinical characteristics explored in association with the 2-year IGF-1 SDS range.

The association between upper-normal IGF-1 SDS and lower body fat percentage was not independent of sex.

• An initial association between upper-normal IGF-1 SDS range and lower body fat percentage was observed.
• This association lost statistical significance after adjusting for sex.
• The loss of significance was attributed to the higher proportion of male patients in the upper-normal IGF-1 SDS group.
• Anthropometric parameters including body fat percentage were among the clinical characteristics explored in the study.