Serum MHRT expression was elevated in CAD and correlated positively with the Gensini score, and HIIT significantly improved cardiopulmonary function and quality of life in CAD patients accompanied by a marked reduction in serum MHRT levels, suggesting MHRT may serve as a potential biomarker for monitoring HIIT efficacy.
Serum MHRT expression was elevated in CAD patients compared to non-CAD volunteers.
Serum MHRT levels correlated positively with the Gensini score, a measure of coronary artery disease severity.
HIIT intervention improved cardiopulmonary function indicators and quality-of-life scores in CAD patients.
Serum MHRT levels decreased after HIIT intervention and were lower in clinically effective responders than in non-responders.
MHRT demonstrated predictive value for CAD diagnosis as assessed by ROC curve analysis and logistic regression.
This research suggests that a molecule called MHRT (Myosin Heavy-Chain-Associated RNA Transcript), which can be measured in the blood, is elevated in patients with coronary artery disease (CAD) and reflects how severe the disease is. The study enrolled 88 CAD patients and compared them to healthy volunteers, finding that higher blood levels of MHRT were associated with more extensive coronary artery blockage as measured by the Gensini score, a standard clinical tool for rating disease severity. The study also investigated whether a structured exercise program called High-Intensity Interval Training (HIIT) could benefit CAD patients and whether MHRT levels would reflect that benefit. After completing HIIT, patients showed improvements in cardiopulmonary (heart and lung) function and quality of life. Importantly, their blood MHRT levels dropped following the exercise program, and patients who responded well clinically had lower MHRT levels than those who did not respond as well. This research suggests that MHRT could serve as a useful blood-based biomarker — a measurable indicator — both for identifying CAD severity and for tracking how well a patient is responding to HIIT rehabilitation. This could potentially help clinicians objectively monitor the effectiveness of cardiac exercise programs, which are an important part of recovery for heart disease patients.
Zhao Y, Zhou X, Yuan G, Yang J. (2026). Myosin Heavy-Chain-Associated RNA Transcript for Cardiopulmonary Recovery Prediction in High-Intensity Interval Training for Coronary Artery Disease.. Journal of visualized experiments : JoVE. https://doi.org/10.3791/71478