Cardiovascular

[Not Available].

TL;DR

Autoimmune primary adrenal insufficiency (Addison's disease) is a rare cause of pericarditis that may have a potentially fatal outcome, so early investigation and treatment are crucial.

Key Findings

A young man with acute chest pain was ultimately suspected of having primary adrenal insufficiency (Addison's disease) after initially being assumed to have pericarditis.

  • He presented with acute chest pain, nausea and vomiting, along with progressive lethargy, an episode of syncope and orthostatic hypotension.
  • A dermatologist had recently noted hyperpigmentation.
  • After admission his chest pain worsened and the ECG showed global ST elevations.
  • Pericarditis was assumed and colchicine treatment was started.

Laboratory and clinical findings pointed to adrenal insufficiency rather than a purely cardiac cause.

  • Tests revealed hyponatraemia, hyperkalaemia and fever.
  • Cardiac troponins were normal.
  • Coronary angiography showed no signs of occlusion.
  • Based on his medical history and clinical findings, primary adrenal insufficiency was suspected.

The patient was treated successfully for adrenal insufficiency and recovered rapidly.

  • The abstract reports 'He was treated successfully, with rapid recovery.'
  • Specific treatment details beyond colchicine are not given in the abstract.

Autoimmune primary adrenal insufficiency is described as a rare cause of pericarditis that can be potentially fatal.

  • The authors state 'to our knowledge' it is a rare cause of pericarditis.
  • They conclude that early investigation and treatment are crucial.
  • This is a single case report, so no incidence or comparative data are provided.

The patient's history included COVID-19 infection and vaccination, which were noted as part of the clinical background.

  • He had COVID-19 during the pandemic and had been vaccinated.
  • The abstract does not state that these were established as causes of the pericarditis.

What This Means

This case report describes a young man who came to hospital with chest pain, nausea, vomiting, fatigue, fainting and low blood pressure on standing. His ECG showed changes consistent with pericarditis (inflammation of the sac around the heart), and he was given colchicine. However, heart-damage blood markers were normal and his coronary arteries were not blocked. Other clues pointed elsewhere: low sodium, high potassium, fever, and darkened skin noted earlier by a dermatologist. These led doctors to suspect Addison's disease, an autoimmune condition in which the adrenal glands fail to make enough hormones. He was treated and recovered quickly. This research suggests that autoimmune adrenal insufficiency can be a rare, potentially life-threatening cause of pericarditis. Because it is a single case, it cannot show how often this happens, but it highlights that unusual combinations of symptoms and lab results may warrant looking for an underlying cause, and that early recognition and treatment matter.

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Citation

Svendsen M, Comi K, Rutherford O. (2026). [Not Available].. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. https://doi.org/10.4045/tidsskr.26.0167