Dietary omega-3 intake was associated with lower depression and stress scores but was not significantly associated with cognitive performance and did not moderate the relationship between mood and memory in healthy adults.
Key Findings
Results
Diets rich in omega-3 sources were associated with lower depression and stress scores.
Dietary patterns including nuts, seeds, fish, and seafood were linked to reduced psychological symptom scores.
Depression was measured using the PHQ-9 and stress using the PSS-10.
The sample consisted of 313 healthy adults who completed a food frequency questionnaire (FFQ).
Results
EPA and DHA, but not ALA, were specifically linked to mood benefits.
Among the specific omega-3 fatty acids quantified, EPA and DHA showed associations with lower depression and stress scores.
Alpha-linolenic acid (ALA) did not show the same mood-related associations.
Precise quantification of EPA, DHA, and ALA intake was performed in a subgroup of 52 older adults using a detailed in-person FFQ.
Results
Dietary omega-3 intake was not significantly associated with cognitive performance.
Cognitive performance included short-term and episodic memory evaluated using Sternberg and Old/New recognition tests.
Omega-3 dietary intake did not moderate the relationship between mood and memory.
This null finding applied across the full sample of 313 healthy adults.
Results
Self-reported omega-3 supplementation was linked to fewer depressive symptoms and better episodic memory.
Unlike dietary omega-3 intake alone, omega-3 supplementation showed associations with both psychological and cognitive outcomes.
Better episodic memory was specifically associated with self-reported supplementation.
This finding was notable because dietary omega-3 intake alone did not show the same cognitive associations.
Conclusions
The role of dietary omega-3 in cognition in healthy adults is not well-established.
The study focused on non-clinical samples of healthy adults.
Dietary omega-3 intake did not significantly predict cognitive performance or moderate mood-cognition relationships.
The authors concluded this area 'warrants further investigation.'
Orłowski J, Kossowska-Wywiał M, Brzezicka A. (2026). Nourishing the Brain or the Mood? Dietary Omega-3s for Psychological, but Not Cognitive Health.. Nutrients. https://doi.org/10.3390/nu18010050