Cardiac myxomas are associated with significant thromboembolic and hemodynamic risks, and early surgical resection provides excellent long-term outcomes and should be considered even in asymptomatic patients.
Key Findings
Results
Thromboembolic events occurred in 18.9% of patients following surgical resection of cardiac myxomas.
Thromboembolic events occurred in 14 of 74 patients (18.9%)
Stroke accounted for 13.5% of events
Embolic myocardial infarction occurred in 2.7% of patients
Pulmonary embolism occurred in 2.7% of patients
The primary outcome was the incidence of thromboembolic events
Results
Postoperative atrial fibrillation was independently associated with a higher hazard of thromboembolic events in multivariable Cox analysis.
HR 6.74 (95% CI 1.490–30.510; p < 0.05)
This association was identified in multivariable Cox regression analysis
Postoperative atrial fibrillation was associated with more than a 6-fold increase in thromboembolic risk
Results
Diabetes was independently associated with a lower hazard of thromboembolic events in multivariable Cox analysis.
HR 0.11 (95% CI 0.006–0.740; p < 0.05)
This was identified in multivariable Cox regression analysis
Diabetes appeared to be a protective factor against thromboembolic events in this cohort
Results
Tumor recurrence occurred in 2.7% of cases over a median follow-up of 60 months.
Tumor recurrence rate was 2.7%
Median follow-up was 60 months (interquartile range 40–79)
Only one death was recorded during the entire follow-up period
Methods
The study cohort consisted of 74 consecutive patients with histologically confirmed cardiac myxomas, with a median age of 60 years and a female predominance.
74 consecutive patients underwent surgical resection between 2014 and 2024 at a tertiary referral center in Brazil
Median age was 60 years (range 52–66)
68.9% of patients were female
All cases were histologically confirmed
Conclusions
Tumor morphology showed a non-significant trend toward higher risk of thromboembolic events.
The association between tumor morphology and thromboembolic events did not reach statistical significance
The paper describes this as 'a non-significant trend toward a higher risk of thromboembolic events'