Pennisetum purpureum Schumach Supplementation Enhances Grip Strength in Adults with Low Muscle Mass: A Randomized Controlled Trial.

Pennisetum purpureum Schumach supplementation significantly increased grip strength after 8 and 12 weeks compared to baseline.

• The experimental group showed a significant increase in grip strength (p < 0.05) after 8 and 12 weeks compared to baseline.
• The trial was 12 weeks in duration, randomized, double-blind, and placebo-controlled.
• The experimental group received 300 mg of Pennisetum purpureum Schumach extract three times daily.
• 35 participants with low muscle mass and reduced muscle strength were enrolled.
• Grip strength was assessed at baseline, 8 weeks, and 12 weeks.

No significant changes in muscle mass were observed in either the experimental or placebo group over the 12-week trial.

• Muscle mass was assessed at baseline, 8 weeks, and 12 weeks.
• The study reported 'no significant changes in muscle mass' in the experimental group.
• Participants were adults with pre-existing low muscle mass and reduced muscle strength.

The 10-meter walk test performance did not significantly change with Pennisetum purpureum Schumach supplementation.

• No significant changes in performance on the 10-meter walk test were observed.
• The 10-meter walk test was assessed at baseline, 8 weeks, and 12 weeks.
• This indicates the supplementation did not measurably affect walking speed or functional mobility.

Liver and kidney function remained unaffected in both the experimental and placebo groups throughout the trial.

• Liver and kidney function were assessed as part of the safety evaluations.
• No significant changes were observed in either group across the 12-week period.
• These findings suggest the supplementation at 300 mg three times daily was safe with respect to hepatic and renal markers.

Some observational variability in testosterone levels was noted among male participants, but no definitive hormonal effects could be determined.

• The study 'lacked the design and statistical power necessary to determine hormonal effects.'
• Testosterone variability was described as observational only, not a statistically confirmed finding.
• Hormonal markers were included as an assessment parameter but yielded no significant findings.
• The authors noted that larger trials with comprehensive parameters are required to evaluate hormonal mechanisms.

The study was a 12-week randomized, double-blind, placebo-controlled trial enrolling 35 adults with low muscle mass and reduced muscle strength.

• Participants were randomized into an experimental group receiving 300 mg Pennisetum purpureum Schumach extract three times daily or a placebo group.
• Assessments were conducted at baseline, 8 weeks, and 12 weeks.
• Outcome measures included grip strength, muscle mass, liver and kidney function, anthropometric measurements, hormonal markers, and the 10-meter walk test.
• The study was double-blind, meaning both participants and investigators were blinded to group assignment.