Mental Health

Perceived control as a resilience factor: associations with neural, physiological and affective stress responses and mental health.

TL;DR

Perceived control may act as a resilience factor, with a high-control class demonstrating more flexible cortisol secretion, greater bilateral posterior insula activation during psychosocial stress, less helplessness, fewer psychosomatic symptoms, and a less external locus of control compared to a low-control class.

Key Findings

Growth mixture modeling of perceived control during an uncontrollable stress task identified two distinct classes: a high-control class and a low-control class.

  • 116 male participants aged 18-30 were included in the study.
  • Perceived control was measured during an uncontrollable stress task separate from the main psychosocial stress task.
  • Growth mixture modeling (GMM) was used to classify participants into latent trajectory classes based on their perceived control responses.
  • The two-class solution yielded a high-control class and a low-control class.

The high-control class experienced less helplessness during the uncontrollability task compared to the low-control class.

  • Helplessness was assessed as an affective response during the uncontrollable stress task.
  • This difference was reported as a key distinguishing feature between the two classes.
  • The finding is consistent with the interpretation that perceived control buffers feelings of helplessness when facing uncontrollable stressors.

The high-control class demonstrated more flexible cortisol responses to a psychosocial stressor compared to the low-control class.

  • Cortisol levels were assessed as an endocrine stress response during a psychosocial stress task (distinct from the uncontrollability task).
  • The cortisol response pattern in the high-control class was characterized as 'more flexible responses to psychosocial stress.'
  • Participants underwent a psychosocial stress task while cortisol was measured.

The high-control class showed greater activation of the bilateral posterior insula during psychosocial stress compared to the low-control class.

  • Neural responses were assessed via functional magnetic resonance imaging (fMRI) during the psychosocial stress task.
  • The bilateral posterior insula was specifically identified as showing differential activation between the two control classes.
  • This activation pattern was interpreted as reflecting more flexible stress processing in the high-control class.

The high-control class reported fewer psychosomatic symptoms and a less external locus of control than the low-control class.

  • General mental health was assessed via self-report measures.
  • Psychosomatic symptoms were among the mental health outcomes showing significant differences between the two classes.
  • Locus of control was also assessed and differed between classes, with the high-control class showing a less external locus of control.
  • These findings link perceived control during a laboratory task to broader indices of mental health.

The study design assessed stress responses across neural, endocrine, and affective domains in response to a psychosocial stressor in a male-only sample.

  • Sample consisted of 116 male participants aged 18-30.
  • Stress responses were assessed via fMRI, cortisol levels, and affective state questionnaires.
  • Participants completed both a psychosocial stress task and a separate uncontrollable stress task.
  • The restriction to male participants limits generalizability; the authors note the need for further research.

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Citation

Meier J, Kollmann B, Meine L, Meyer B, Yuen K, Stork M, et al.. (2026). Perceived control as a resilience factor: associations with neural, physiological and affective stress responses and mental health.. Translational psychiatry. https://doi.org/10.1038/s41398-025-03786-6