Phase angle shows a significant negative relationship with HbA1c levels in adults with type 1 diabetes mellitus, suggesting it can be used as a clinical indicator of improved blood glucose control beyond being a simple body composition parameter.
Key Findings
Results
Phase angle was negatively correlated with HbA1c levels in adults with type 1 diabetes mellitus.
56 adults with T1DM aged between 18 and 70 years were included in the cross-sectional study.
Pearson's correlation analysis indicated a negative correlation between phase angle and HbA1c levels.
Linear regression models confirmed the negative association between phase angle and HbA1c levels.
The negative correlation remained significant after controlling for age and weight in both males and females.
Conclusions
Phase angle was identified as a potential early-warning clinical indicator of glycaemic control in adults with type 1 diabetes mellitus.
The study collected data on body composition parameters including phase angle values alongside laboratory indicators including HbA1c levels.
The authors concluded that phase angle can be used as a clinical indicator of improved blood glucose control beyond being a simple body composition parameter.
The study suggests phase angle warrants further exploration as an early warning indicator of blood glucose control in patients with poor glycaemic control of T1DM.
Methods
The study design was cross-sectional and included a relatively small sample of 56 adult T1DM patients.
Participants were adults with T1DM aged between 18 and 70 years.
Both body composition data (including phase angle) and laboratory indicators (including HbA1c) were collected.
Statistical analysis included Pearson's correlation and linear regression models.
Analyses were conducted with adjustment for age and weight, and were performed separately for males and females.
Zhang L, Zhu J, Yang F, Cui T, Xi X, Yang L, et al.. (2026). Phase angle as an early-warning indicator of glycaemic control in adults with type 1 diabetes mellitus: a cross-sectional study.. Frontiers in endocrinology. https://doi.org/10.3389/fendo.2026.1793935