Body Composition

Phase angle as an early-warning indicator of glycaemic control in adults with type 1 diabetes mellitus: a cross-sectional study.

TL;DR

Phase angle shows a significant negative relationship with HbA1c levels in adults with type 1 diabetes mellitus, suggesting it can be used as a clinical indicator of improved blood glucose control beyond being a simple body composition parameter.

Key Findings

Phase angle was negatively correlated with HbA1c levels in adults with type 1 diabetes mellitus.

  • 56 adults with T1DM aged between 18 and 70 years were included in the cross-sectional study.
  • Pearson's correlation analysis indicated a negative correlation between phase angle and HbA1c levels.
  • Linear regression models confirmed the negative association between phase angle and HbA1c levels.
  • The negative correlation remained significant after controlling for age and weight in both males and females.

Phase angle was identified as a potential early-warning clinical indicator of glycaemic control in adults with type 1 diabetes mellitus.

  • The study collected data on body composition parameters including phase angle values alongside laboratory indicators including HbA1c levels.
  • The authors concluded that phase angle can be used as a clinical indicator of improved blood glucose control beyond being a simple body composition parameter.
  • The study suggests phase angle warrants further exploration as an early warning indicator of blood glucose control in patients with poor glycaemic control of T1DM.

The study design was cross-sectional and included a relatively small sample of 56 adult T1DM patients.

  • Participants were adults with T1DM aged between 18 and 70 years.
  • Both body composition data (including phase angle) and laboratory indicators (including HbA1c) were collected.
  • Statistical analysis included Pearson's correlation and linear regression models.
  • Analyses were conducted with adjustment for age and weight, and were performed separately for males and females.

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Citation

Zhang L, Zhu J, Yang F, Cui T, Xi X, Yang L, et al.. (2026). Phase angle as an early-warning indicator of glycaemic control in adults with type 1 diabetes mellitus: a cross-sectional study.. Frontiers in endocrinology. https://doi.org/10.3389/fendo.2026.1793935