Physical activity and risk of adverse events in atrial fibrillation: evidence from European and Asian cohorts.

Physically active AF patients had a significantly lower risk of the composite outcome of all-cause death and MACE compared to inactive patients.

• HR 0.66 (95% CI 0.56–0.78) for the composite outcome in active vs. inactive patients
• Active patients were defined as those exercising ≥3 h/week; inactive as no exercise or <3 h/week
• Median follow-up was 514 days
• No significant interaction between physical activity and ethnicity (pinteraction = 0.298)

Physically active AF patients had significantly lower all-cause mortality compared to inactive patients.

• HR 0.52 (95% CI 0.42–0.65) for all-cause death
• Analysis performed using Cox proportional hazards models
• Findings were consistent across European and Asian cohorts

Physically active AF patients had lower risks of MACE and cardiovascular death.

• MACE HR 0.80 (95% CI 0.65–0.99)
• Cardiovascular death HR 0.60 (95% CI 0.42–0.86)
• These findings were secondary outcomes of the analysis

The risk of the composite outcome decreased progressively with increasing levels of physical activity.

• A dose-response relationship was observed between physical activity level and composite outcome risk
• No significant interaction between physical activity level and ethnicity (pinteraction = 0.845)
• This pattern was consistent across both European and Asian populations

The majority of AF patients in both cohorts were physically inactive.

• Of 13,126 total participants, 9,487 (72%) were physically inactive and 3,639 (28%) were physically active
• Mean age was 69 ± 12 years; 39% were female
• Data were drawn from post-hoc analysis of two prospective registries from Europe and the Asia-Pacific

Asian AF patients differed from European AF patients in clinically relevant characteristics.

• Asians had lower odds of obesity, symptomatic AF, and heart failure compared to Europeans
• Asians had higher odds of cardiovascular risk factors than Europeans
• These differences were observed across both physically active and inactive groups

No significant difference in the association between physical activity and major bleeding risk was reported as a notable secondary finding.

• Major bleeding was included as a secondary outcome
• The abstract does not report a statistically significant HR for major bleeding, suggesting no significant association was found
• Primary protective associations were observed for death and MACE outcomes