Physical Activity Modifies the Association between C-Reactive Protein - Triglyceride - Glucose Index (CTI) and Dyslipidemia: Evidence from a 10-Year Chinese Cohort.

Each 1-unit increase in CTI corresponded to approximately a 9% higher risk of incident dyslipidemia over 10 years of follow-up.

• HR = 1.09, 95% CI: 1.01-1.18 for each 1-unit increase in CTI
• 7,954 participants aged ≥45 years without dyslipidemia at baseline were enrolled
• 2,011 new cases of dyslipidemia were recorded during the 10-year follow-up (2011-2020)
• Cox proportional hazards regression with restricted cubic splines was applied to evaluate associations
• CTI was derived from high-sensitivity C-reactive protein, fasting plasma glucose, and triglyceride levels

Individuals in the highest CTI quartile had a 15% greater risk of incident dyslipidemia compared with those in the lowest quartile.

• HR = 1.15, 95% CI: 1.01-1.30 for highest vs. lowest CTI quartile
• Analysis was conducted in the full cohort of 7,954 participants
• Incident dyslipidemia was defined based on abnormal lipid profiles, ongoing lipid-lowering treatment, or a physician's clinical diagnosis

The association between CTI and dyslipidemia risk was stronger in men than in women, with no significant effect observed in women.

• HR for men = 1.20, 95% CI: 1.05-1.36 per 1-unit increase in CTI
• No significant association was found in women
• Stratified analyses by sex were performed using Cox proportional hazards regression

The association between CTI and dyslipidemia risk was stronger in adults aged 45-59 years compared with the overall cohort.

• HR = 1.22, 95% CI: 1.08-1.39 per 1-unit increase in CTI in the 45-59 age group
• Stratified analyses by age group were performed
• All participants were aged ≥45 years at baseline

Physical activity modified the association between CTI and dyslipidemia risk, with the highest risk increase observed in the vigorous activity group.

• A 1-unit CTI increase was linked to approximately a 10% higher risk in the light and moderate physical activity groups
• A 1-unit CTI increase was linked to approximately a 28% higher risk in the vigorous physical activity group
• Risk was observed to plateau at higher CTI levels in the vigorous activity group
• Physical activity was assessed using the CHARLS physical activity questionnaire capturing frequency and duration of vigorous, moderate, and light activities
• Participants were categorized into low, moderate, and high physical activity groups based on frequency and duration

The study used data from the China Health and Retirement Longitudinal Study (CHARLS) spanning 2011-2020 with a prospective cohort design.

• 7,954 participants aged ≥45 years without dyslipidemia at baseline were enrolled
• Follow-up period was 10 years
• Participants were middle-aged and older Chinese adults
• Cox proportional hazards regression with restricted cubic splines was the primary analytical approach
• Stratified analyses were conducted by sex, age, and physical activity level