Cardiovascular

Physiotherapy implementation and hospitalisation-associated disability according to prehospital functional status in older patients with heart failure: a secondary analysis of a prospective nationwide multicentre registry.

TL;DR

Greater implementation of in-hospital physiotherapy, including higher number of modalities, frequency, and amount, was consistently associated with lower hospitalisation-associated disability incidence across all prehospital functional status subgroups in older patients with heart failure, with particular benefit observed for higher modality use and frequency in patients with reduced baseline functional status.

Key Findings

Hospitalisation-associated disability (HAD) occurred in 37.1% of older patients hospitalised with acute heart failure who received in-hospital physiotherapy.

  • Study included 9448 patients with heart failure from a nationwide registry across 96 sites in Japan.
  • Median patient age was 83 years; all patients were aged ≥65 years.
  • HAD was defined as a ≥5-point decrease in the Barthel Index (BI) score at discharge compared with the prehospital level.
  • 3503 of 9448 patients experienced HAD.

Greater physiotherapy implementation across all measured dimensions was consistently associated with lower HAD incidence across all prehospital functional status subgroups.

  • Physiotherapy dimensions examined included number of modalities, frequency per week, and amount per week.
  • The five modality types assessed were basic out-of-bed activity, gait exercise, low-intensity muscle training, aerobic exercise, and resistance training.
  • Associations were analysed using logistic regression analyses stratified by prehospital BI levels (≥85, 60–80, and <60).
  • The association was consistent across all three prehospital BI subgroups.

Effect modification by prehospital functional status was observed for physiotherapy modality number in patients with prehospital BI 60–80.

  • P for interaction = .048 for modality number in patients with prehospital BI 60–80, compared with patients with prehospital BI ≥85.
  • This indicates that the benefit of greater number of physiotherapy modalities was differentially stronger in patients with intermediate baseline functional impairment (BI 60–80).
  • Analyses were stratified by three prehospital BI levels: ≥85, 60–80, and <60.

Effect modification by prehospital functional status was observed for physiotherapy frequency in patients with prehospital BI <60.

  • P for interaction = .045 for physiotherapy frequency in patients with prehospital BI <60, compared with patients with prehospital BI ≥85.
  • This indicates that higher physiotherapy frequency per week was differentially more beneficial for patients with the lowest baseline functional status.
  • Patients with prehospital BI <60 represent the most functionally impaired subgroup in this study.

The study was a prospective observational design using a nationwide multicentre registry, limiting causal inference.

  • The study is described as a secondary analysis of a prospective observational registry.
  • Data were collected across 96 sites in Japan.
  • The observational design means that residual confounding cannot be excluded, and the findings reflect associations rather than confirmed causal effects.
  • The registry included only patients who received in-hospital physiotherapy, potentially limiting generalisability to those who did not receive physiotherapy.

The authors concluded that greater in-hospital physiotherapy implementation has potential benefit for preventing HAD, particularly for higher modality use and frequency in patients with reduced baseline functional status.

  • The paper states: 'This large registry revealed the potential benefit of greater implementation of in-hospital physiotherapy for preventing HAD, particularly for higher modality use and frequency in patients with reduced baseline functional status.'
  • The findings suggest that physiotherapy intensity and diversity may need to be tailored to patients' prehospital functional level.
  • The results are framed as 'potential benefit' given the observational study design.

What This Means

This research examined whether more intensive physical therapy during hospitalization could help older heart failure patients avoid losing their ability to perform daily activities — a phenomenon called hospitalisation-associated disability (HAD). Using data from nearly 9,500 patients aged 65 and older admitted to 96 hospitals across Japan, the researchers found that over one-third of patients (37.1%) experienced meaningful functional decline during their hospital stay, defined as a notable drop in their ability to perform everyday tasks like eating, bathing, and walking. The study found that patients who received more types of physical therapy exercises, more frequent sessions, and greater overall amounts of therapy were less likely to experience this functional decline, regardless of how physically capable they were before being hospitalized. Importantly, patients who were already somewhat functionally limited before admission appeared to benefit even more from receiving a greater variety of therapy types and more frequent therapy sessions — suggesting that the sickest and most vulnerable patients may stand to gain the most from intensive rehabilitation efforts during hospitalization. This research suggests that optimizing in-hospital physical therapy — both in terms of how often it is delivered and how many different types of exercises are included — may be an important strategy for preserving functional independence in older adults hospitalized with heart failure. The findings are particularly relevant for patients who already have some degree of disability before hospitalization, as these individuals may benefit most from more intensive and varied therapy programs. Because this was an observational study, it cannot definitively prove that more therapy directly causes better outcomes, but the consistency of findings across different patient groups strengthens the case for further investigation.

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Citation

Hamazaki N, Kato M, Iida Y, Iwata K, Sakurada K, Funami Y, et al.. (2026). Physiotherapy implementation and hospitalisation-associated disability according to prehospital functional status in older patients with heart failure: a secondary analysis of a prospective nationwide multicentre registry.. Age and ageing. https://doi.org/10.1093/ageing/afag283