AMR is an independent predictor of LVEF at half-year post-procedure and has significant predictive value for reduced left ventricular systolic function, potentially playing an important role in predicting the prognosis of STEMI patients.
AMR was identified as an independent predictive factor for LVEF at half-year follow-up in STEMI patients after primary PCI.
AMR demonstrated a statistically significant but moderate ability to predict reduced left ventricular systolic function (LVEF < 0.5) by ROC curve analysis.
Peak creatine kinase (CK) and NT-proBNP were the strongest independent predictors of LVEF at half-year follow-up among the variables analyzed.
Age was identified as an independent predictor of LVEF at half-year follow-up in STEMI patients.
Five independent predictive factors for LVEF at half-year follow-up were identified: age, peak CK, TnT, NT-proBNP, and AMR.
This research suggests that a measure called angio-based microvascular resistance (AMR) — calculated from routine coronary angiography images taken right after a heart attack procedure — can help predict how well a patient's heart will be pumping six months later. In a study of 194 patients who had a serious type of heart attack (STEMI) treated with emergency artery-opening procedures (primary PCI), higher AMR values after the procedure were associated with weaker heart function at the six-month follow-up. An AMR value above 250.5 mmHg·s/m was identified as the threshold most useful for flagging patients at risk of reduced heart pumping function. AMR was one of five factors independently linked to worse heart function at follow-up, alongside older age, higher peak levels of heart damage markers (creatine kinase and troponin T), and elevated NT-proBNP (a marker of heart stress). While AMR showed a statistically significant predictive ability, its accuracy was moderate (area under the ROC curve of 0.631), meaning it adds useful information but is not highly precise on its own. This research suggests that measuring microvascular resistance immediately after a heart attack procedure — without needing additional specialized equipment beyond standard angiography — could help doctors identify which patients are at higher risk of developing lasting heart weakness. This could potentially guide closer monitoring or more aggressive treatment for higher-risk patients in the months following a heart attack.
Liu D, Zhou J, Han J. (2026). [Prognostic value of angio-based microvascular resistance on left ventricular systolic function in patients with acute ST-segment elevation myocardial infarction].. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. https://pubmed.ncbi.nlm.nih.gov/42880919/