Propensity score analysis of triglyceride-glucose index in newly diagnosed patients with essential hypertension as a predictor of microalbuminuria.

The optimal TyG index cutoff value for predicting microalbuminuria in newly diagnosed hypertensive patients was 9.125, determined by ROC analysis.

• ROC analysis was used to identify the cutoff value of 9.125 for the TyG index.
• The cohort consisted of 2,052 newly diagnosed hypertensive patients from Changde Hospital, China, enrolled between January 2020 and December 2024.
• Patients were divided into two groups: high TyG index (≥9.125) and low TyG index (<9.125).

The high TyG index group exhibited significantly higher rates of microalbuminuria compared to the low TyG index group after propensity score matching.

• Propensity score matching (PSM) was employed to balance baseline differences between the low and high TyG index groups.
• The adjusted odds ratio (OR) for MAU in the high TyG index group was 2.37 (95% CI 1.73–3.26).
• Logistic regression models were used to analyze the association between TyG index and MAU in both original and matched cohorts.

The association between the TyG index and microalbuminuria was non-linear, following an L-shaped pattern with a marked increase in MAU prevalence in the high TyG group.

• The analysis revealed a non-linear, L-shaped association between TyG index and MAU.
• A marked increase in the prevalence of MAU was observed in the high TyG group.
• This non-linear relationship suggests a threshold effect around the cutoff value of 9.125.

Sensitivity analyses using inverse probability treatment weighting (IPTW) reinforced the finding that a high TyG index is associated with increased risk of microalbuminuria.

• Inverse probability treatment weighting (IPTW) was used as a sensitivity analysis to confirm the robustness of findings.
• The high TyG index group consistently showed a higher risk of MAU across both original and matched cohorts.
• Subgroup analyses were also conducted to evaluate the robustness of the findings.

The TyG index is described as a simple and accessible biomarker for early detection of kidney damage in newly diagnosed hypertensive patients.

• The study population comprised 2,052 newly diagnosed patients with essential hypertension.
• The TyG index provides valuable insight for early detection of kidney damage in this population.
• The TyG index has emerged as a potential predictor for microalbuminuria (MAU) in patients with essential hypertension.