Purified Anthocyanins Indicated No Significant Effect on Arterial Stiffness, Four-Limb Blood Pressures and Cardiovascular Risk-A 12-Week Dose-Response Trial in Chinese Middle-Aged and Elderly Adults with Hyperglycemia.

Purified anthocyanin supplementation showed no significant effects or dose-response relationships on arterial stiffness as measured by brachial-ankle pulse wave velocity.

• Four groups were compared: placebo, 160, 320, and 640 mg/day ACNs
• Brachial-ankle pulse wave velocity (baPWV) was used as the primary measure of arterial stiffness
• No significant dose-response relationship was observed across the three active doses
• The trial duration was 12 weeks

Anthocyanin supplementation had no significant effect on ankle-brachial index (ABI) or four-limb blood pressures.

• Vascular function was assessed using both baPWV and ABI measurements
• Four-limb blood pressures were measured as part of the vascular assessment
• No significant changes were observed across any of the ACN dosage groups compared to placebo
• Results were consistent across 160, 320, and 640 mg/day doses

Anthocyanin supplementation demonstrated no significant effects on composite cardiovascular risk indices.

• Composite cardiovascular indices were estimated based on lipids and anthropometric data
• No significant treatment effects were found for any cardiovascular risk factor measured
• Baseline characteristics were generally comparable among the four groups
• The study population consisted of Chinese middle-aged and elderly adults with either prediabetes or early diabetes

The trial recruited 184 eligible participants, with 19 withdrawals during the 12-week intervention period.

• Participants were randomly assigned to placebo or ACN groups with n = 46 per group at baseline
• 19 participants withdrew during the intervention, leaving 165 completers
• The study was a double-blind, randomized, placebo-controlled design
• This report was a secondary analysis based on the parent trial
• Participants were Chinese middle-aged and elderly adults with hyperglycemia (prediabetes or early diabetes)

The study population targeted individuals with dysglycemia, as diabetes is associated with sub-optimal vascular function.

• Eligible participants had either prediabetes or early diabetes
• Diabetes is noted as being associated with sub-optimal vascular function
• Information on dietary intakes and lifestyle habits and blood samples were collected at baseline and at week 12
• Prior evidence had suggested purified anthocyanins could improve cardio-metabolic health, but dose-response effects on arterial stiffness had not been previously verified