A combined oral supplement and topical serum regimen produced a statistically significant and clinically meaningful reduction in grey hair over 24 weeks versus baseline and placebo, which the authors attribute to synergistic effects of the two products.
The combination of supplement plus serum significantly reduced the number of grey hairs from baseline at both 12 and 24 weeks.
The placebo group experienced a worsening of grey hair over the study, and the combination group differed significantly from placebo at week 24.
Photo grading and participant self-assessment confirmed the objective reduction in grey hair in the combination group.
The trial was a randomized, double-blind, placebo-controlled study with four arms testing each component alone and together.
The authors attribute the benefit to synergistic effects of the oral supplement's proprietary blend and the patented topical serum.
Grey hair is highly prevalent, and no treatment had previously been shown in a clinical trial to repigment or slow grey hair development.
This study tested whether a daily oral supplement combined with a scalp serum could reduce grey hair. A total of 173 adults aged 28 to 65 with a modest amount of grey hair (5–25%) were randomly assigned to one of four groups: supplement plus serum, supplement alone, serum alone, or placebo for both. Neither participants nor researchers knew who got which product. People using both the supplement and the serum had about 9% fewer grey hairs after 12 weeks and about 13% fewer after 24 weeks compared with where they started. Over the same period, the placebo group's grey hairs increased by nearly 10%. Photo grading and participants' own observations agreed with the hair counts. The authors suggest the effect came from the two products working together. This research suggests that a combined oral and topical approach may reduce grey hair, which no treatment had previously been shown to do in a clinical trial. The abstract does not give detailed results for the supplement-only or serum-only groups, and the products were made by the company that sponsored the research, so larger and independent studies would help confirm the findings.
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Upload Your LabsBhardwaj V, Rodgers N, Oliveira C, Qin E, Conrad A, Conrad K. (2026). Randomized Double-Blind, Placebo-Controlled Study of a Supplement and Serum on Grey Hair.. Journal of drugs in dermatology : JDD. https://doi.org/10.36849/JDD.932701