Recurrent bowel angioedema in a patient with C1 esterase inhibitor deficiency.

A 56-year-old male patient presented with recurrent abdominal pain, nausea, and vomiting secondary to bowel angioedema caused by C1 esterase inhibitor deficiency.

• The patient experienced recurrent bowel obstruction secondary to angioedema
• The condition resulted in multiple hospitalisations and surgical interventions
• The patient was male, aged 56 years old
• The case involved C1 esterase inhibitor (C1-INH) deficiency as the underlying cause

Bowel angioedema due to C1-INH deficiency can present without concomitant facial or peripheral angioedema.

• The patient lacked concomitant facial or peripheral angioedema, which are more commonly associated features of C1-INH deficiency
• The case demonstrates that isolated bowel involvement is a recognized presentation of C1-INH deficiency
• Late onset of presentation was noted as an atypical feature in this case

C1-INH deficiency, including both hereditary and acquired forms, should be considered in the differential diagnosis of recurrent abdominal pain and bowel oedema.

• Both hereditary and acquired forms of C1-INH deficiency were reviewed in this case report
• The authors reviewed clinical presentation, laboratory evaluation, and management of C1-INH deficiency
• Recurrent bowel obstruction secondary to angioedema is described as uncommon
• The case highlights that late onset and atypical presentation should not exclude C1-INH deficiency from consideration