Cardiovascular

Recurrent brief positional vertigo as the initial presentation of medial branch of the posterior inferior cerebellar artery territory cerebellar infarction: a case report.

TL;DR

mPICA territory infarction may mimic BPPV as brief recurrent positional vertigo, and in older patients with vascular risk factors, persistent or atypical positional vertigo warrants repeated neurological examination and early MRI-DWI.

Key Findings

A cerebellar infarction in the medial branch of the posterior inferior cerebellar artery (mPICA) territory presented with recurrent brief positional vertigo, mimicking benign paroxysmal positional vertigo (BPPV).

  • The patient was a 63-year-old man with poorly controlled hypertension.
  • Vertigo was triggered mainly by lying down, getting up, or turning over in bed.
  • Initial neurological examination, positional tests, and cranial CT were all unremarkable.
  • BPPV was initially considered but could not be confirmed.

Initial standard diagnostic workup failed to identify the cerebellar infarction, and the correct diagnosis was only established after persistent symptoms and new neurological signs prompted MRI-DWI.

  • Initial cranial CT was unremarkable.
  • Initial neurological examination and positional tests did not reveal a central cause.
  • Persistent attacks followed by spontaneous horizontal nystagmus and mild left-sided dysmetria prompted further imaging.
  • MRI-DWI revealed acute infarction in the medial left cerebellar hemisphere and vermis.

The development of spontaneous horizontal nystagmus and mild left-sided dysmetria were the clinical signs that led to the correct diagnosis of cerebellar infarction.

  • These signs appeared after persistent vertigo attacks.
  • Their emergence prompted MRI-DWI imaging.
  • MRI-DWI confirmed acute infarction in the medial left cerebellar hemisphere and vermis.
  • These signs represent key 'red flags' distinguishing central from peripheral vestibular pathology in this case.

Following antiplatelet and statin therapy, the patient achieved complete symptom resolution with an excellent functional outcome at all follow-up intervals.

  • The patient was treated with antiplatelet and statin therapy.
  • He remained symptom-free at 1-month, 3-month, and 6-month follow-up.
  • Modified Rankin Scale (mRS) score was 0 at follow-up, indicating no symptoms or disability.

Older patients with vascular risk factors presenting with persistent or atypical positional vertigo should undergo repeated neurological examination and early MRI-DWI to exclude posterior circulation ischemia.

  • Isolated episodic vertigo is usually attributed to peripheral vestibular disorders but may uncommonly represent posterior circulation ischemia.
  • Brief recurrent positional vertigo caused by mPICA territory infarction is described as uncommon.
  • The case highlights that initial negative workup including CT does not exclude cerebellar infarction.
  • Poorly controlled hypertension was the primary vascular risk factor identified in this patient.

What This Means

This case report describes a 63-year-old man with high blood pressure who experienced repeated brief episodes of dizziness triggered by changes in head position, such as lying down, getting up, or rolling over in bed. Initially, doctors suspected a common inner ear condition called benign paroxysmal positional vertigo (BPPV), and early tests including a CT scan and neurological examination appeared normal. However, because the episodes kept recurring and the patient later developed additional symptoms — uncontrolled eye movements and difficulty with coordination on his left side — doctors performed an MRI scan, which revealed a small stroke in the cerebellum, the part of the brain responsible for balance and coordination. This research suggests that a specific type of cerebellar stroke, affecting a region supplied by the medial branch of the posterior inferior cerebellar artery (mPICA), can closely mimic BPPV by causing brief, position-triggered dizziness. This is important because BPPV is a benign condition, while a stroke requires prompt medical treatment to prevent further events. The patient was treated with antiplatelet medication and a cholesterol-lowering drug (statin), and he had no further symptoms and full functional recovery over six months of follow-up. The case highlights a diagnostic pitfall: standard early tests such as CT scans and routine neurological exams can miss small cerebellar strokes, potentially delaying treatment. This research suggests that in older patients with cardiovascular risk factors like high blood pressure who have persistent or unusual positional dizziness, doctors should consider repeating neurological examinations over time and obtaining an MRI with diffusion-weighted imaging (MRI-DWI), which is more sensitive for detecting early stroke, even if initial tests appear normal.

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Citation

Zhang S, Xie Y, Hu Z, Chen Y, Su Y, Ma Z. (2026). Recurrent brief positional vertigo as the initial presentation of medial branch of the posterior inferior cerebellar artery territory cerebellar infarction: a case report.. BMC neurology. https://doi.org/10.1186/s12883-026-05299-1