Image fusion guidance was associated with reduced contrast media usage and radiation exposure during endovascular embolization of PAVMs, without compromising procedural outcomes.
Key Findings
Results
Image fusion guidance significantly reduced contrast media consumption during PAVM embolization procedures.
Median contrast dose was 0.18 g I/kg in the image fusion group compared to 0.62 g I/kg in the control group
This represents an approximately 71% reduction in contrast media use
The difference was statistically significant (p = 0.001)
22 procedures used image fusion guidance; 16 procedures served as controls
Results
Radiation exposure as measured by dose-area product (DAP) was significantly lower in the image fusion guidance group.
Median DAP was 22.4 Gy·cm² in the image fusion group versus 86.6 Gy·cm² in the control group
This represents an approximately 74% reduction in DAP
The difference was statistically significant (p = 0.04)
DAP was used as an indirect measure of radiation exposure
Results
Fluoroscopy time was significantly shorter in procedures using image fusion guidance.
Median fluoroscopy time was 31.2 minutes in the image fusion group compared to 55.7 minutes in the control group
This represents an approximately 44% reduction in fluoroscopy time
The difference was statistically significant (p = 0.04)
Fluoroscopy time was used as an additional indirect measure of radiation exposure
Methods
The study was a retrospective analysis of 38 endovascular embolization procedures for PAVMs conducted at a single tertiary care university hospital.
Procedures were performed between 2009 and 2022
22 procedures employed image fusion guidance and 16 procedures served as the control group
Key metrics compared included contrast media usage, dose-area product, and fluoroscopy time
The study design was observational and retrospective
Conclusions
Image fusion guidance was associated with reductions in contrast and radiation without compromising procedural outcomes.
The authors characterize the findings as 'supportive rather than definitive evidence'
No compromise in procedural outcomes was reported with the use of image fusion guidance
The authors call for confirmation in prospective studies
Results are described as observational and from a single center
What This Means
This research suggests that using a technique called image fusion guidance during a minimally invasive procedure to treat pulmonary arteriovenous malformations (PAVMs) — abnormal connections between blood vessels in the lungs — can substantially reduce patients' exposure to both contrast dye and X-ray radiation. The study compared 22 procedures that used image fusion (which overlays pre-existing CT scan images onto live X-ray imaging to help guide the procedure) against 16 procedures performed without this technology. Procedures using image fusion required about 71% less contrast dye, 74% less radiation dose, and took about 44% less fluoroscopy (live X-ray) time.
These reductions matter because contrast dye can stress the kidneys and cause allergic reactions, while repeated or high radiation exposure carries long-term health risks. Shorter procedure times with less radiation and contrast could be particularly beneficial for patients who need multiple treatments or who already have compromised kidney function. The improved guidance from fused imaging may help doctors navigate more precisely to the target blood vessels without needing as many contrast dye injections to visualize the anatomy.
This research suggests image fusion guidance is a promising tool for improving the safety profile of PAVM embolization procedures, but the authors themselves note these are observational findings from a single hospital over 13 years and should be confirmed in larger, prospectively designed studies before drawing firm conclusions.
Said H, Lehti L, Dias N, Elf J, Zarrouk M. (2026). Reduced radiation and contrast dose using image fusion guidance during endovascular embolization of pulmonary arteriovenous malformations.. Scandinavian cardiovascular journal : SCJ. https://doi.org/10.1080/14017431.2026.2722550