The EASIX score was independently associated with the presence of coronary artery ectasia and demonstrated moderate discriminative ability, with an odds ratio of 2.12 in multivariable logistic regression analysis.
Patients with coronary artery ectasia had significantly higher EASIX scores compared with controls.
ROC analysis demonstrated moderate discriminative ability of the EASIX score for predicting coronary artery ectasia.
EASIX score was identified as an independent predictor of coronary artery ectasia in multivariable logistic regression analysis.
The study was a retrospective case-control analysis of 300 patients who underwent coronary angiography.
This research suggests that a blood test score called EASIX — calculated from three routine lab values (LDH, creatinine, and platelet count) — is significantly elevated in patients who have coronary artery ectasia (CAE), a condition where the coronary arteries become abnormally widened rather than narrowed. The study compared 150 CAE patients to 150 patients without the condition, all of whom had undergone coronary angiography, and found that the EASIX score was about 50% higher on average in the CAE group. Statistical analysis confirmed that this association held up even after accounting for other factors, with patients having higher EASIX scores being about twice as likely to have CAE. The EASIX score showed moderate ability to distinguish CAE patients from non-CAE patients, with an AUC of 0.688. At a cut-off value of 0.74, it correctly identified 72% of CAE cases (sensitivity) but only correctly ruled out the condition in 58% of non-CAE patients (specificity), meaning it performs better as a screening tool than a definitive diagnostic test. The researchers believe this score reflects underlying endothelial dysfunction and systemic inflammation, which are thought to play a role in the development of CAE. This research suggests that EASIX — a simple, inexpensive score derived from standard laboratory tests — could potentially serve as an additional tool to help clinicians identify patients at risk for CAE. However, because the study was retrospective and had only moderate discriminative accuracy, further prospective research would be needed to establish its clinical utility more firmly.
Aydin C, Orta H, Demirkiran A, Emlek N. (2026). Relationship between Endothelial Activation and Stress Index and Coronary Artery Ectasia.. Arquivos brasileiros de cardiologia. https://doi.org/10.36660/abc.20260242