Low testosterone levels, clinical hypogonadism, and androgen deprivation therapy-induced testosterone deficiency are significantly associated with male depression, and testosterone replacement therapy may have a good therapeutic effect on male depression.
Key Findings
Background
Low testosterone levels are significantly associated with male depression.
Testosterone is synthesized and secreted through the hypothalamic-pituitary-gonadal (HPG) axis and plays a regulatory role in men's mental health.
Low testosterone levels may serve as a characteristic biomarker of male depression risk.
The mechanisms by which low testosterone influences depression remain uncertain and are subject to ongoing investigation.
Background
Clinical hypogonadism is significantly associated with male depression.
The paper identifies clinical hypogonadism as one of three key testosterone-related conditions associated with male depression.
The mechanistic pathways linking clinical hypogonadism to depressive symptoms remain incompletely understood.
Hypogonadism is discussed in the context of mood regulation in men.
Background
Androgen deprivation therapy (ADT)-induced testosterone deficiency is significantly associated with male depression.
ADT is a clinical intervention that induces testosterone deficiency and is linked to depressive outcomes in men.
ADT-induced testosterone deficiency is listed alongside low testosterone and clinical hypogonadism as significantly associated with male depression.
The mechanisms underlying ADT-related depression remain uncertain.
Background
Testosterone replacement therapy (TRT) may have a therapeutic effect on male depression.
The paper proposes that TRT 'may have a good therapeutic effect on male depression.'
TRT is discussed as a potential intervention given that low testosterone may serve as a biomarker for depression risk.
The paper focuses on assessing the role of testosterone levels and related clinical therapies in mood regulation in men.
Background
The hypothalamic-pituitary-gonadal (HPG) axis plays a central regulatory role in testosterone synthesis and men's mental health.
Testosterone is synthesized and secreted through the HPG axis.
The HPG axis is described as playing 'a regulatory role in men's mental health.'
Disruption of HPG axis function is implicated in the relationship between testosterone deficiency and depression.
Fu J, Guo Q, Chen X. (2025). Research Progress in the Role of Testosterone in Male Depression.. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. https://doi.org/10.3881/j.issn.1000-503X.16142