Resistance training enhances weight-loss quality by maximizing fat mass reduction while preserving or increasing fat-free mass during calorie-restricted diet programs in both men and women.
Key Findings
Results
Total weight loss was similar across exercise groups in men despite differences in body composition outcomes.
Men's total weight loss: NO: -8.5 kg ± 3.2 kg; AR: -9.0 kg ± 4.2 kg; RT: -7.7 kg ± 4.2 kg
Study included 183 men and 121 women aged 20-74 years with BMI 18.5-45 kg/m²
Mean follow-up was 5.1 months ± 0.42 months
Diet was designed to provide an individualized energy deficit of approximately 500 kcal/day calculated relative to each participant's measured RMR and total estimated daily energy expenditure
Body composition was assessed using dual-energy X-ray absorptiometry (DXA)
Results
In men, resistance training produced the greatest fat mass reduction and was the only modality associated with an increase in fat-free mass.
Fat mass reduction in men: RT: -8.9 kg ± 4.1 kg; AR: -7.8 kg ± 3.2 kg; NO: -5.8 kg ± 2.5 kg
Fat-free mass change in men: RT: +0.8 kg ± 5.0 kg; AR: -1.1 kg ± 2.0 kg; NO: -2.8 kg ± 1.4 kg
RT was the only modality associated with an increase in fat-free mass in men
Both aerobic exercise and no exercise groups lost fat-free mass in men
Results
In men, abdominal circumference declined in all groups but with larger reductions in resistance training and aerobic exercise compared to no exercise.
ABC reductions in men: RT: -9.0 cm ± 3.7 cm; AR: -8.0 cm ± 3.2 cm; NO: -6.1 cm ± 2.4 cm
All three groups showed significant reductions in abdominal circumference
RT and AR both produced larger ABC reductions compared with NO
Results
In women, resistance training produced the greatest fat mass reduction and was the only modality that increased fat-free mass.
Total weight loss in women: NO: -7.13 kg ± 3.27 kg; AR: -6.43 kg ± 3.53 kg; RT: -5.42 kg ± 3.76 kg
Fat mass reduction in women: RT: -6.36 kg ± 3.82 kg; NO: -5.47 kg ± 2.64 kg; AR: -4.10 kg ± 3.17 kg
Fat-free mass change in women: RT: +0.90 kg ± 1.24 kg; NO: -2.94 kg ± 1.40 kg; AR: -0.37 kg ± 1.45 kg
RT was the only modality that increased FFM in women; both NO and AR experienced FFM loss
Results
The fat mass-to-weight loss ratio was highest in the resistance training group, indicating superior weight loss quality.
Lahav Y, Yavetz R, Gepner Y. (2026). Resistance training as a key strategy for high-quality weight loss in men and women.. Frontiers in endocrinology. https://doi.org/10.3389/fendo.2025.1725500