Risk factors associated with cardiac dysfunction in men with erectile dysfunction.

BMI was independently associated with increased odds of both LV systolic and diastolic dysfunction in men with erectile dysfunction.

• Study included 398 men with ED recruited from a urology outpatient clinic and through invitations to randomly selected men >40 years.
• In multivariable analysis, BMI was associated with LV systolic dysfunction (OR 1.08; 95% CI: 1.01-1.15).
• BMI was also associated with LV diastolic dysfunction (OR 1.09; 95% CI: 1.00-1.19).
• BMI was the only risk factor that remained significant for both types of cardiac dysfunction in multivariable analyses.

Diastolic blood pressure was independently associated with increased odds of LV systolic dysfunction in men with ED.

• Diastolic blood pressure was associated with LV systolic dysfunction in univariable analyses.
• In multivariable analysis, diastolic blood pressure remained significant (OR 1.04; 95% CI: 1.01-1.07).
• Diastolic blood pressure was not reported as a significant factor for LV diastolic dysfunction.

HbA1c was independently associated with increased odds of LV systolic dysfunction in multivariable analysis.

• HbA1c remained significant in multivariable analysis for LV systolic dysfunction (OR 1.06; 95% CI: 1.01-1.12).
• HbA1c was not highlighted as a significant predictor of LV diastolic dysfunction.
• HbA1c was among the clinical variables examined alongside age, BMI, blood pressure, lipid profile, high-sensitivity C-reactive protein, and cardiovascular comorbidities.

Dyslipidemia was independently associated with increased odds of LV diastolic dysfunction in men with ED.

• In multivariable analysis, dyslipidemia was associated with LV diastolic dysfunction (OR 2.54; 95% CI: 1.11-5.72).
• Dyslipidemia was not reported as a significant independent predictor of LV systolic dysfunction.
• This association was identified in a cross-sectional design, precluding causal inference.

High-sensitivity C-reactive protein was associated with increased odds of LV systolic dysfunction in univariable but not multivariable analysis.

• Univariable analyses showed that BMI, diastolic blood pressure, and high-sensitivity C-reactive protein were associated with increased odds of LV systolic dysfunction.
• High-sensitivity C-reactive protein did not remain significant in the multivariable model for LV systolic dysfunction.
• This suggests its association may be confounded by other cardiometabolic risk factors included in the multivariable model.

The study used echocardiography to assess left ventricular systolic and diastolic dysfunction in a cross-sectional cohort of 398 men with erectile dysfunction.

• Men were recruited from a urology outpatient clinic and through invitations to randomly selected men >40 years.
• Echocardiography was used to assess both LV systolic and diastolic dysfunction.
• Clinical variables examined included age, BMI, blood pressure, lipid profile, HbA1c, high-sensitivity C-reactive protein, and cardiovascular comorbidities.
• The study was prospectively registered at ClinicalTrials.gov (NCT05285280).
• The cross-sectional design precludes causal inference.