Increasing age and primary snoring may be independently associated with hypertension among pediatric patients attending the sleep clinic, with hypertension detected in 41% of patients with complete ambulatory blood pressure monitoring data.
Key Findings
Results
Hypertension was diagnosed in 41% of pediatric sleep clinic patients with complete ABPM data.
Of 44 patients with complete ABPM data, 18/44 (41%) were diagnosed with hypertension.
10 patients (23%) had ambulatory hypertension and 8 patients (18%) had masked hypertension (MH).
68 total patients were recruited; 14 (21%) did not return for ABPM and 10 (15%) had insufficient readings, leaving 44 with complete data.
Median age of the cohort was 12.6 years (IQR 10.0–14.7).
Results
Age was independently associated with hypertension in pediatric sleep clinic patients.
Relative risk (RR) for age was 1.27 (95% CI 1.07–1.52, p = 0.008).
This association was identified through multivariable analysis.
The finding suggests that for each additional year of age, the risk of hypertension increased by approximately 27%.
Results
Primary snoring was independently associated with hypertension in pediatric sleep clinic patients.
Relative risk (RR) for primary snoring was 3.52 (95% CI 1.38–8.97, p = 0.004).
3/17 (18%) of hypertensive patients who completed a sleep study had primary snoring.
The prevalence of hypertension among patients with primary snoring was 3/5 (60%), higher than among those with mild OSA (6/20, 30%), moderate OSA (4/10, 40%), or severe OSA (4/8, 50%).
Primary snoring was a stronger independent risk factor for hypertension than OSA severity in this cohort.
Results
Hypertension prevalence increased with OSA severity but was highest among patients with primary snoring.
Hypertension prevalence was 30% (6/20) in mild OSA, 40% (4/10) in moderate OSA, and 50% (4/8) in severe OSA.
Hypertension prevalence among patients with primary snoring was 60% (3/5).
Among the 18 hypertensive patients, one defaulted the sleep study; of the remaining 17, 18% had primary snoring, 35% had mild OSA, 24% had moderate OSA, and 24% had severe OSA.
Methods
A substantial proportion of recruited patients were unable to complete ABPM, limiting the evaluable sample size.
68 patients aged 5–18 years were recruited from a pediatric sleep clinic in this prospective cohort study.
14 patients (21%) did not return for the ABPM appointment.
10 patients (15%) had insufficient ABPM readings.
Only 44 patients (65% of recruited) had complete ABPM data available for analysis.
ABPM was classified based on the 2022 update on ABPM in children from the American Heart Association.
Results
Masked hypertension, which requires ABPM for diagnosis, accounted for nearly half of all hypertension cases detected.
8 of 18 hypertensive patients (18% of all 44 patients with complete data) had masked hypertension (MH).
MH would not have been detected without ABPM, as it presents with normal clinic blood pressure.
The authors note that ABPM is required to diagnose both white coat hypertension (WCH) and masked hypertension (MH), but is not routinely performed.
Polysomnography (PSG) or overnight pulse oximetry (OPO) were performed as per standard of care alongside ABPM.
What This Means
This research suggests that high blood pressure (hypertension) is very common in children referred to a sleep clinic, affecting about 41% of those who completed blood pressure monitoring. The study used a device called a 24-hour ambulatory blood pressure monitor (ABPM), which patients wear throughout the day and night to get a more accurate picture of blood pressure than a single clinic measurement. This approach is important because it can detect 'masked hypertension,' where blood pressure appears normal in the clinic but is actually high at other times — a condition that would otherwise go unnoticed. In this study, nearly half of the hypertensive cases were masked hypertension.
Surprisingly, the study found that children with primary snoring — meaning they snore but do not have obstructive sleep apnea (OSA) — actually had the highest rate of hypertension (60%) compared to children with mild, moderate, or severe OSA. Older age and primary snoring were the two factors most strongly and independently linked to hypertension. This challenges the assumption that hypertension risk in sleep clinic patients is driven mainly by OSA severity.
This research suggests that routine blood pressure monitoring, ideally with ABPM, may be valuable for all children attending sleep clinics — not just those with the most severe sleep-disordered breathing. The authors caution that the study was small (only 44 patients with complete data) and conducted at a single center, so larger studies are needed to confirm these findings. Nevertheless, the results highlight that primary snoring and increasing age should be considered when assessing cardiovascular risk in pediatric sleep patients.
Leow E, Cheng Z, Wang F, Du R, Ho J, Yap C, et al.. (2026). Risk factors associated with hypertension in patients attending a pediatric sleep clinic: a prospective cohort study.. European journal of pediatrics. https://doi.org/10.1007/s00431-026-07513-1