Serum 25-Hydroxyvitamin D3 Status in Adolescents With Anxiety Disorders: A Case-Control and Vitamin D Supplementation Substudy.

Mean serum 25-(OH)D3 levels were significantly lower in adolescents with anxiety disorders compared to healthy controls.

• The experimental group (n=124) had a mean serum 25-(OH)D3 level of (16.48 ± 6.53) ng/ml.
• The control group (n=131) had a mean serum 25-(OH)D3 level of (22.95 ± 7.25) ng/ml.
• The difference was statistically significant (p < 0.05).
• Participants were adolescents from the pediatric outpatient department of Jingzhou First People's Hospital from January 2020 to December 2022.

The prevalence of vitamin D deficiency and insufficiency was substantially higher in adolescents with anxiety disorders than in healthy controls.

• 69.35% of the experimental group (adolescents with anxiety disorders) had vitamin D deficiency or insufficiency.
• 36.64% of the control group (healthy adolescents) had vitamin D deficiency or insufficiency.
• The difference in prevalence between groups was statistically significant (p < 0.05).

Anxiety scores were negatively correlated with serum 25-(OH)D3 levels in adolescents with anxiety disorders.

• Simple linear regression analysis was used to evaluate the predictive capacity of 25-(OH)D3 levels on anxiety scores in the experimental group.
• Lower 25-(OH)D3 levels were associated with higher anxiety scores.
• The analysis indicated that 25-(OH)D3 levels demonstrated some predictive value for anxiety disorders.

Vitamin D supplementation for 12 weeks reduced anxiety scores in adolescents with anxiety disorders who had vitamin D deficiency or insufficiency.

• 86 adolescents with anxiety disorders and 25-(OH)D deficiency or insufficiency from the experimental group received vitamin D supplementation.
• Supplementation duration was 12 weeks.
• Anxiety scores were measured before and after supplementation, and results showed reduced anxiety scores following supplementation.
• This substudy assessed the effect of 25-(OH)D3 levels on anxiety disorders through pre- and post-supplementation comparison.

Vitamin D deficiency was identified as a potential risk factor for anxiety disorders in adolescents with some predictive value for these conditions.

• The study was a case-control design with a supplementation substudy.
• The experimental group consisted of 124 adolescents with anxiety disorders and the control group consisted of 131 healthy adolescents.
• The authors concluded that vitamin D supplementation could potentially alleviate anxiety symptoms in adolescents.
• The study aimed to provide clinical evidence for the diagnosis and treatment of pediatric anxiety disorders.