Serum Retinol-Binding Protein 4 Levels in Hypertensive and Normotensive Individuals.

Mean serum RBP4 was significantly higher in hypertensive individuals than in normotensive individuals.

• Mean serum RBP4 in the hypertensive group was 62.17 ± 28.22 ng/mL compared to 14.70 ± 5.59 ng/mL in the normotensive group.
• Statistical analysis used an independent sample t-test with p ≤ 0.05 considered statistically significant.
• The difference was described as statistically significant, suggesting RBP4's 'potential as a biomarker.'
• Analysis was performed using SPSS version 26.

The study enrolled equal numbers of hypertensive and normotensive non-obese adult participants.

• A total of 82 participants were enrolled: 41 hypertensive and 41 normotensive subjects.
• All participants were aged ≥40 years.
• 46% of participants were male.
• Mean age was 53.69 ± 9.86 years in the hypertensive group and 52.41 ± 6.30 years in the normotensive group.

Hypertension and normotension were defined using JNC 8 criteria with specific blood pressure thresholds.

• Hypertension was defined as blood pressure ≥140/90 mmHg.
• Normotension was defined as blood pressure <120/80 mmHg in the absence of antihypertensive medication.
• The study specifically enrolled non-obese individuals to control for obesity as a confounding variable.
• Serum RBP4 was measured using a Human RBP4 ELISA kit from 5 mL of venously collected blood.

This was a cross-sectional study design comparing RBP4 levels between hypertensive and normotensive groups.

• The cross-sectional design limits causal inference between RBP4 levels and hypertension.
• Blood was collected aseptically before serum analysis.
• The study focused specifically on non-obese individuals, distinguishing the hypertension-RBP4 relationship from obesity-related confounding.