Sexual Health

Sexual Health in Patients with Atopic Dermatitis: A Cross-Sectional Study.

TL;DR

AD significantly affects patients' quality of life, including their sex life, with many factors associated with the disease contributing to the deterioration of patients' sexual health, suggesting routine assessment of sexual life in dermatological practice using validated tools.

Key Findings

Patients with atopic dermatitis had significantly higher anxiety scores than healthy controls.

  • Mean anxiety scores: 6.8 ± 3.6 in AD patients vs. 5.0 ± 3.2 in healthy controls (p < 0.001)
  • Study enrolled 201 participants: 96 patients with AD and 105 healthy controls
  • Anxiety was measured using the Hospital Anxiety and Depression Scale (HADS)
  • Female AD patients reported higher anxiety compared to male AD patients (7.6 ± 2.9 vs. 6.0 ± 4.1, p = 0.03)

Patients with atopic dermatitis had significantly higher depression scores than healthy controls.

  • Mean depression scores: 5.2 ± 3.4 in AD patients vs. 3.9 ± 2.9 in healthy controls (p < 0.01)
  • Depression was measured using the Hospital Anxiety and Depression Scale (HADS)
  • Female AD patients reported higher depression scores compared to male AD patients (5.9 ± 3.1 vs. 4.4 ± 3.5, p = 0.03)

Patients with atopic dermatitis had significantly worse quality of life scores than healthy controls.

  • Mean DLQI scores: 12.3 ± 6.1 in AD patients vs. 1.8 ± 3.1 in healthy controls (p < 0.001)
  • Quality of life was assessed using the Dermatology Life Quality Index (DLQI)
  • AD severity was assessed using the SCORAD questionnaire

Patients with atopic dermatitis had significantly higher skin-related sexual dysfunction scores than healthy controls.

  • Mean skin-related sexual life quality (SRSLQ) scores: 15.0 ± 4.5 in AD patients vs. 4.4 ± 4.7 in healthy controls (p < 0.001)
  • Sexual dysfunction was assessed using the Skin-Related Sexual Life Quality (SRSLQ) scale
  • Additional sexual function measures included the Female Sexual Function Index (FSFI) and International Index of Erectile Function (IIEF-5)

Female patients with atopic dermatitis reported significantly lower sexual function scores compared to healthy women.

  • Mean FSFI scores: 24.8 ± 8.0 in female AD patients vs. 31.3 ± 3.0 in healthy women (p < 0.001)
  • Sexual function in women was measured using the Female Sexual Function Index (FSFI)
  • Female AD patients also reported higher values of depression and anxiety compared to male AD patients

Deterioration in sexual health was strongly correlated with quality of life impairment, anxiety, and depression in AD patients.

  • SRSLQ score correlated with QoL impairment (R = 0.5, p < 0.001)
  • SRSLQ score correlated with anxiety (R = 0.51, p < 0.001)
  • SRSLQ score correlated with depression (R = 0.5, p < 0.001)

Sexual life quality negatively correlated with multiple AD-specific clinical factors.

  • Sex life negatively correlated with AD severity (p = 0.001)
  • Sex life negatively correlated with involvement of the genital area (p = 0.005)
  • Sex life negatively correlated with intensity of pruritus (r = 0.284, p = 0.005)
  • Sex life negatively correlated with insomnia (r = 0.366, p < 0.001)

What This Means

This research suggests that atopic dermatitis (AD), a chronic inflammatory skin condition commonly known as eczema, has a significant negative impact on patients' sexual health, in addition to the already well-known effects on mental well-being and quality of life. In a study of 201 participants (96 with AD and 105 healthy controls), people with AD reported notably higher levels of anxiety, depression, and skin-related sexual difficulties compared to those without the condition. Women with AD were particularly affected, showing lower sexual function scores and higher rates of anxiety and depression than both healthy women and male AD patients. The study also found that sexual health problems in AD patients were closely linked to the severity of the disease and specific symptoms. Worse itching (pruritus), sleep problems (insomnia), involvement of the genital skin area, and more severe overall disease were all associated with poorer sexual quality of life. Additionally, sexual dysfunction was strongly correlated with impaired quality of life, anxiety, and depression, suggesting these issues reinforce one another. This research suggests that sexual health is an important but often overlooked dimension of care for people with atopic dermatitis. The authors recommend that dermatologists routinely assess patients' sexual well-being using validated questionnaire tools, which could help identify those who are struggling and connect them with appropriate support earlier in their care.

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Citation

Ju&#x15b;ko N, Masajada M, &#x17b;ab&#xf3;wka A, &#x106;miel A, Brzewski P, Reich A. (2025). Sexual Health in Patients with Atopic Dermatitis: A Cross-Sectional Study.. Medicina (Kaunas, Lithuania). https://doi.org/10.3390/medicina61101782