Short Sleep Duration Is Positively Associated With Traditional and Non-Traditional Markers of Adiposity and Cardiometabolic Risk in Individuals at Secondary Healthcare: A Cross-Sectional Study.
E Oliveira N, Filgueiras M, et al. • FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2026
Short sleep duration was positively associated with abdominal obesity, overweight, high visceral adiposity index, high triglyceride-glucose index, and high diastolic blood pressure in individuals at secondary healthcare, while long sleep duration showed no association with cardiometabolic risk.
Key Findings
Results
The prevalence of short sleep was 9.8% and long sleep was 36.7% in the secondary healthcare population studied.
Short sleepers averaged 5.9 ± 0.7 hours per night
Long sleepers averaged 10.5 ± 1.3 hours per night
Sleep durations were self-reported and classified according to National Sleep Foundation criteria
The study enrolled 937 men and women aged ≥18 years assisted at Secondary Healthcare
The study design was cross-sectional using secondary data
Results
Short sleep duration was positively associated with abdominal obesity independent of confounders.
Prevalence ratio (PR): 1.15; 95% CI: 1.01–1.23
Abdominal obesity was measured using waist circumference as a traditional marker of adiposity
Association remained significant after adjustment for potential confounders
Statistical analysis used Poisson regression models at α = 0.05
Results
Short sleep duration was positively associated with overweight independent of confounders.
Prevalence ratio (PR): 1.11; 95% CI: 1.00–1.24
Overweight was assessed using body mass index (BMI) as a traditional marker of adiposity
Association was statistically significant after adjustment for potential confounders
BMI was classified among the traditional markers of adiposity and cardiometabolic risk
Results
Short sleep duration was positively associated with high visceral adiposity index (VAI), a non-traditional marker of cardiometabolic risk.
Prevalence ratio (PR): 1.36; 95% CI: 1.04–1.77
VAI was classified as a non-traditional marker of adiposity and cardiometabolic risk
Other non-traditional markers assessed included deep-abdominal-adipose-tissue index, lipid accumulation product index, Castelli risk index 1 and 2, TG/HDL-c ratio, atherogenic index of plasma, and triglyceride-glucose index
Association was independent of confounders
Results
Short sleep duration was positively associated with a high triglyceride-glucose (TyG) index, a marker of insulin resistance.
Prevalence ratio (PR): 1.44; 95% CI: 1.09–1.89
The TyG index was classified as a non-traditional marker of cardiometabolic risk
This association suggests a link between short sleep and insulin resistance
Association remained significant after adjustment for potential confounders
Results
Short sleep duration was positively associated with high diastolic blood pressure (DBP).
Prevalence ratio (PR): 1.35; 95% CI: 1.07–1.72
Both systolic (SBP) and diastolic blood pressure were included as traditional markers of cardiometabolic risk
The association was specific to diastolic blood pressure; systolic blood pressure was not reported as significantly associated
Association was independent of confounders
Results
Long sleep duration was not associated with any traditional or non-traditional markers of cardiometabolic risk.
No statistically significant associations were found between long sleep and any of the adiposity or cardiometabolic markers examined
Long sleepers averaged 10.5 ± 1.3 hours per night and represented 36.7% of the sample
This null finding contrasts with the multiple significant associations observed for short sleep
Analyses were conducted using Poisson regression models adjusted for potential confounders
Results
Short sleep duration was not significantly associated with traditional lipid or glucose markers such as triglycerides, glucose, and glycated hemoglobin in adjusted models.
Traditional markers assessed included triglycerides, glucose, and glycated hemoglobin, in addition to waist circumference, BMI, and blood pressure
Significant associations for short sleep were limited to abdominal obesity, overweight, VAI, TyG index, and DBP
The authors concluded that short sleep is linked to 'adiposity-related risk, insulin resistance, and diastolic blood pressure imbalance'
What This Means
This research suggests that sleeping too little — defined as fewer hours than recommended by the National Sleep Foundation — is linked to a cluster of health risks including excess belly fat, overall overweight, greater visceral (deep internal) fat accumulation, signs of insulin resistance, and higher diastolic blood pressure (the lower number in a blood pressure reading). The study examined nearly 1,000 adults receiving care at a secondary healthcare facility, meaning patients who already face elevated cardiovascular risk. About 1 in 10 participants were short sleepers (averaging under 6 hours per night), while over a third were long sleepers (averaging over 10 hours per night).
Interestingly, sleeping too much was not associated with any of the cardiometabolic risk markers studied, even though long sleep was far more common in this group. The associations for short sleep held up after accounting for other factors that could explain the results, strengthening the case that sleep duration itself may play a role in metabolic and cardiovascular health. The study used both traditional risk measures (like BMI and blood pressure) and newer, less commonly used markers (like the visceral adiposity index and the triglyceride-glucose index) to get a more complete picture of cardiometabolic risk.
This research suggests that short sleep duration may be an important but often overlooked factor contributing to poor metabolic and cardiovascular health, particularly among people who are already at elevated risk. Because this was a cross-sectional study (a snapshot in time), it cannot establish that short sleep directly causes these health problems — it only shows that they tend to occur together. Nonetheless, the findings highlight the potential value of assessing sleep habits as part of cardiovascular risk evaluation in clinical settings.
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E Oliveira N, Filgueiras M, Zanirate G, Cândido F, Ribeiro S, Hermsdorff H. (2026). Short Sleep Duration Is Positively Associated With Traditional and Non-Traditional Markers of Adiposity and Cardiometabolic Risk in Individuals at Secondary Healthcare: A Cross-Sectional Study.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.202602078RR