Myo-reps and traditional straight-sets produced similar muscle size and strength adaptations over 8 weeks, but Myo-reps required significantly less session time and approximately 30% less volume load.
Key Findings
Results
Myo-reps produced a statistically significant reduction in session duration compared to traditional straight-sets.
The acute crossover study used a sample of n=9 subjects who completed both protocols
Session duration difference was statistically significant (p < 0.001)
The exercises used for comparison were flat barbell bench press protocols
No specific time values (in minutes) were reported in the abstract, only the statistical significance of the difference
Results
Muscle excitation as measured by electromyography did not differ significantly between Myo-reps and traditional straight-sets in the acute study.
EMG was used to measure muscle excitation during both protocols
No statistically significant difference was found (p = 0.374)
The acute study used a crossover design with n=9 subjects
A linear positioning transducer was also used alongside EMG to assess mechanical output
Results
Mean barbell velocity did not differ significantly between Myo-reps and traditional straight-sets in the acute study.
Mean barbell velocity was measured using a linear positioning transducer
No statistically significant difference was found (p = 0.766)
Both muscle excitation and barbell velocity results suggest similar neuromuscular demands between the two protocols acutely
The crossover design with n=9 subjects allowed within-subject comparisons
Results
Both Myo-reps and traditional straight-sets groups showed statistically significant increases in muscle size over 8 weeks, with no significant difference between groups.
The 8-week study involved n=22 subjects divided into two groups
Both groups showed significant increases in muscle size (p < 0.001)
No between-group differences were observed for muscle size
Exercises performed were flat barbell bench press, incline barbell bench press, and seated cable fly, twice weekly
Results
Both Myo-reps and traditional straight-sets groups showed statistically significant increases in strength over 8 weeks, with no significant difference between groups.
Both groups showed significant increases in strength (p < 0.001)
No between-group differences were observed for strength
Strength endurance was also assessed as an outcome measure
Participants were resistance-trained men
Results
The Myo-reps group performed approximately 30% less volume load than the traditional straight-sets group over the 8-week intervention.
The difference in volume load between groups was statistically significant (p = 0.001)
The Myo-reps group performed 'approximately 30% less VL than the TRA group'
Despite lower volume load, the Myo-reps group achieved similar muscle size and strength outcomes
This finding supports the time-efficiency of the Myo-reps protocol
Conclusions
The study concluded that Myo-reps can be a viable option to achieve similar hypertrophic and strength results in less time compared to traditional straight-sets.
No differences were observed between groups on muscle excitation, mean barbell velocity, muscle size, or strength
Myo-reps achieved equivalent outcomes with significantly less session time and approximately 30% less volume load
The authors stated: 'MYO can still be a viable option to achieve similar results in less time'
The study design included both an acute crossover component (n=9) and an 8-week longitudinal component (n=22)
What This Means
This research suggests that a training method called 'Myo-reps' — where you perform a moderate set to near-failure, rest briefly, and then repeat in small clusters — can produce the same gains in muscle size and strength as traditional sets with longer rest periods between them. Over an 8-week study with 22 resistance-trained men performing chest exercises twice per week, both training groups got significantly stronger and built similar amounts of muscle, with no meaningful difference between the two approaches. In a separate acute test with 9 participants, the two methods also produced the same level of muscle electrical activity (measured by EMG) and the same barbell speed, suggesting the muscles are being challenged similarly during each approach.
The key practical difference was efficiency: the Myo-reps group completed their workouts in significantly less time and lifted about 30% less total volume (total weight × reps) while achieving the same results. This means the Myo-reps format may allow people to get equivalent training benefits with shorter workouts. This research suggests that for people who are time-constrained or looking for ways to maintain their training results with less volume, Myo-reps could be a practical and effective alternative to traditional resistance training sets.
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Bradshaw J, Sanzo K, Barakat C, Barshun A, Inglima S, Gotla T, et al.. (2026). Similar Strength and Hypertrophic Adaptations in Less Time? Myo-Reps vs. Traditional Straight-Sets in Resistance-Trained Men.. Journal of strength and conditioning research. https://doi.org/10.1519/JSC.0000000000005388