Older adults with epilepsy exhibited significantly poorer sleep quality compared to controls, with sleep disturbances closely linked to epilepsy-related factors including age of onset, epilepsy duration, and seizure frequency.
Key Findings
Results
Older adults with epilepsy had significantly higher global PSQI scores than controls, indicating worse overall sleep quality.
Mean global PSQI score was 6.1 (SD 3.3) in older adults with epilepsy (OAE) versus 4.6 (SD 3.2) in controls (p < 0.001).
The study used a case-control design with 175 OAE and 700 older adults without epilepsy.
Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), with scores > 5 indicating poor sleep.
Results
Nearly half of older adults with epilepsy were classified as poor sleepers, compared to roughly one-fifth of controls.
48.6% of OAE were classified as poor sleepers versus 19.9% of controls (p < 0.001).
This represents more than a twofold higher prevalence of poor sleep in OAE compared to controls.
Results
Older adults with epilepsy showed impairment across multiple PSQI sleep domains compared to controls.
OAE had longer sleep latency, shorter sleep duration, lower sleep efficiency, more sleep disturbances, higher frequency of sleeping medication use, and greater daytime dysfunction compared to controls.
All differences across these domains were statistically significant (all p < 0.05).
Results
Poor sleepers in the OAE group had worse sleep characteristics compared to poor sleeper controls.
Poor sleepers in the OAE group exhibited shorter sleep duration, more severe sleep disturbances, and greater daytime dysfunction compared to poor sleeper controls (p < 0.05).
Results
Later age of epilepsy onset was associated with greater sleep disturbances and less sleep medication use.
Epilepsy onset at older age was associated with greater sleep disturbances (β = 0.006, p = 0.005).
Epilepsy onset at older age was associated with less sleep medication use (β = -0.011, p = 0.009).
Findings were derived from multivariate linear regression models.
Results
Longer epilepsy duration was associated with fewer sleep disturbances but more sleep medication use.
Longer epilepsy duration was correlated with fewer sleep disturbances (β = -0.006, p = 0.006).
Longer epilepsy duration was correlated with more sleep medication use (β = 0.011, p = 0.008).
These associations were identified in multivariate linear regression models.
Results
Higher seizure frequency was associated with shorter sleep duration in older adults with epilepsy.
Higher seizure frequency was associated with shorter sleep duration (β = -0.228, p = 0.023).
This association was identified through multivariate linear regression modeling controlling for other variables.
What This Means
This research suggests that older adults living with epilepsy experience significantly worse sleep than their peers without epilepsy. In a study comparing 175 older adults with epilepsy to 700 older adults without epilepsy, nearly half (48.6%) of the epilepsy group had poor sleep quality, compared to only about one in five (19.9%) of those without epilepsy. People with epilepsy took longer to fall asleep, slept for shorter periods, had less efficient sleep, experienced more nighttime disturbances, used more sleep medications, and had more difficulty functioning during the day.
The research also found that specific features of a person's epilepsy were linked to their sleep problems. People who developed epilepsy later in life tended to have more sleep disturbances but used fewer sleep medications, while those who had lived with epilepsy for longer had fewer sleep disturbances but used more sleep medications. Additionally, those who had more frequent seizures slept for shorter durations overall. These patterns suggest that the relationship between epilepsy and sleep is complex and changes over the course of the condition.
This research suggests that sleep problems are a common and serious issue for older adults with epilepsy, and that clinicians should routinely assess and address sleep quality as part of epilepsy care in this population. Better management of seizures and tailored attention to sleep may help improve the overall health and quality of life of older people living with epilepsy.
Fan Y, Zhou X, Ping H, Chen Y, Zhao Q, Ding D, et al.. (2026). Sleep quality and impact factors in older adults with epilepsy.. Epilepsy & behavior : E&B. https://doi.org/10.1016/j.yebeh.2026.110889