Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity.

In univariate analysis, VAT, ASAT, IMAAT, and hepatic fat were all significantly associated with cardiometabolic risk score.

• Associations ranged from β = 0.308 to 0.526, p ≤ 0.001
• Sample included 114 children with overweight/obesity (54.4% girls, mean age 10.6 ± 1.1 years)
• Fat depots were measured using magnetic resonance imaging
• Cardiometabolic risk score was age- and sex-reference based

In univariate analysis, VAT, ASAT, IMAAT, and hepatic fat were all significantly associated with insulin resistance.

• Associations ranged from β = 0.227 to 0.412, p < 0.05
• Insulin resistance was calculated using age- and sex-reference based methods
• Cardiometabolic risk factors assessed included blood pressure, triglycerides, HDL cholesterol, glucose, and insulin

After adjusting for other fat variables, VAT was the only fat depot independently associated with cardiometabolic risk score.

• β = 0.450, p < 0.001 after multivariate adjustment
• Hepatic fat did not show an independent association with cardiometabolic risk score (p ≥ 0.256)
• ASAT and IMAAT lost independent significance for cardiometabolic risk score after mutual adjustment

After adjusting for other fat variables, ASAT was the only fat depot independently associated with insulin resistance.

• β = 0.393, p < 0.001 after multivariate adjustment
• Hepatic fat did not show an independent association with insulin resistance (p ≥ 0.256)
• VAT and IMAAT lost independent significance for insulin resistance after mutual adjustment

Lumbar spine bone marrow fat and pancreatic fat were not significantly associated with cardiometabolic risk score or insulin resistance.

• These depots were measured using magnetic resonance imaging alongside VAT, ASAT, IMAAT, and hepatic fat
• Neither depot appeared among the significant univariate associations reported (β = 0.308–0.526 for significant depots)
• The study included six distinct fat depots: abdominal visceral, subcutaneous, intermuscular adipose tissue, lumbar spine bone marrow, hepatic, and pancreatic fat