Antiaging strategies including exercise, caloric restriction, balanced diet, weight management, diabetes control, and smoking cessation can prevent and treat aging-related diseases by boosting testosterone production and improving health outcomes in long-term sedentary aging males.
Key Findings
Background
Physical inactivity is the fourth leading cause of early death globally, with a substantial proportion of the world's population insufficiently active.
31% of the world's population is not getting enough physical activity
Physical inactivity ranks as the fourth leading cause of early death globally
The WHO recommends adults perform 150-300 min of moderate-intensity activity per week, or 75-150 min of vigorous-intensity activity, or an equivalent combination
Background
Testosterone levels in men decline progressively starting from 30 to 40 years of age and continue declining until death.
Low testosterone levels begin declining from 30 to 40 years of age
The decline in testosterone continues until death
Aging is defined by rapid decline in physical activity, loss of mobility, and premature morbidity
Results
Exercise significantly boosts testosterone production in elderly men, with effects varying based on multiple exercise parameters.
Exercise increases muscle steroidogenesis, total testosterone, and free testosterone in the elderly
Testosterone levels vary based on type, frequency, volume, intensity, and duration of exercise
Regular exercise is identified as one of the key antiaging strategies that can prevent and treat aging-related diseases
Results
Testosterone replacement therapy in elderly men improves multiple physiological and cognitive outcomes.
Testosterone replacement therapy improves physical function, strength, and protein synthesis
Additional benefits include improvements in cholesterol, bone density, sexual desire, and erectile function
Overall cognition is also improved with testosterone replacement therapy in elderly men
Results
Dehydroepiandrosterone (DHEA) supplementation may provide health improvements without negative effects in aging males.
Some studies suggest DHEA supplementation may potentially reverse arterial aging
DHEA supplementation may reduce the risk of cardiovascular diseases
DHEA is presented as potentially providing health improvements without the negative effects associated with other therapies
Results
Emerging antiaging therapeutic approaches include senolytic therapeutics targeting cellular senescence and stem cell transplantation.
Senolytic therapeutics focus on cellular senescence as a mechanism of antiaging intervention
Stem cell transplantation investigates the therapeutic potential of older stem cells
These approaches are identified alongside lifestyle-based antiaging strategies such as caloric restriction, balanced diet, and weight management