[Testosterone replacement therapy and possible side effects].

Testosterone replacement therapy has documented effects on bone metabolism.

• Bone metabolism is identified as a key area affected by testosterone substitution.
• The paper reviews testosterone's role in bone health as part of its side effect and effect profile.
• Skeletal effects are listed among the primary focus areas of the review.

Testosterone replacement therapy has implications for cardiac function.

• Cardiac function is highlighted as one of the key areas of concern in testosterone substitution.
• The review addresses cardiovascular effects as part of the mandatory knowledge base for prescribers.
• Heart effects ('Herz') are listed as a primary focus area of the paper.

Testosterone replacement therapy involves psychosexual interactions.

• Psychosexual interferences ('psychosexuelle Interferenzen') are identified as a primary area of effect.
• Sexuality is listed among the key domains affected by testosterone substitution.
• These effects are framed as both intended effects and potential side effects of therapy.

Gynecomastia is identified as a side effect of testosterone replacement therapy.

• Gynecomastia ('Gynäkomastie') is explicitly listed as one of the primary focus areas of the review.
• It is categorized among the side effects that prescribers must have knowledge of.
• The paper addresses gynecomastia within the broader context of mandatory side effect awareness.

Testosterone replacement therapy affects fertility and can serve as a contraceptive.

• Fertility and contraception ('Fertilität und Kontrazeption') are identified as a key focus area.
• The dual role of testosterone in both impairing fertility and serving as contraception is addressed.
• This area is highlighted as part of the essential knowledge for testosterone substitution management.

The relationship between prostate carcinoma and testosterone replacement therapy is identified as an area of tension.

• The paper describes prostate carcinoma and testosterone replacement as a 'Spannungsfeld' (area of tension/conflict).
• Prostate carcinoma concerns are listed as one of the primary focus areas requiring mandatory knowledge.
• This topic is framed as requiring careful consideration alongside other side effects of testosterone substitution.