Testosterone Replacement Therapy and Associated Rates of Trigger Finger, de Quervain Tenosynovitis, and Their Subsequent Management.

Patients undergoing TRT were more than twice as likely to develop trigger finger compared to matched controls.

• Study used a one-to-one exact matched retrospective cohort design from a large nationwide claims database
• Records queried between 2010 and 2019 for adult patients who filled a prescription for TRT for 3 consecutive months
• Both unadjusted and adjusted odds ratios (OR) were reported; adjusted OR for trigger finger exceeded 2.0
• Single-variable chi-square analyses and multivariable logistic regression were used to control for potential confounding variables

TRT was associated with an increased likelihood of developing de Quervain tenosynovitis.

• Rates of new onset de Quervain tenosynovitis were identified using ICD-9, ICD-10, and CPT billing codes
• Adjusted odds ratios were reported after controlling for potential confounding variables via multivariable logistic regression
• The study evaluated outcomes over a 2-year period following TRT use

TRT patients diagnosed with trigger finger were roughly twice as likely to undergo steroid injections or surgical release compared to controls.

• Analysis was restricted to patients diagnosed with trigger finger over the 2-year period
• Both steroid injection and surgical release rates were assessed using CPT billing codes
• Patients with prior TRT were approximately twice as likely to require these interventions compared to matched controls

TRT patients diagnosed with de Quervain tenosynovitis were roughly twice as likely to undergo steroid injections or surgical release compared to controls.

• Analysis was restricted to patients diagnosed with de Quervain tenosynovitis over the 2-year period
• Both steroid injection and surgical release rates were assessed using CPT billing codes
• Patients with prior TRT were approximately twice as likely to require these interventions compared to matched controls

There is a paucity of prior evidence associating physiologic testosterone replacement therapy with tenosynovitis of the hand.

• Anabolic steroid therapy has been previously associated with tendon injury, but physiologic TRT had not been well studied in this context
• The study specifically focused on trigger finger and de Quervain tenosynovitis as distinct clinical conditions
• This study was designed to fill the evidence gap regarding TRT at physiologic doses and hand tenosynovitis