Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency.

Testosterone undecanoate treatment was significantly associated with lower AMSS values compared with baseline/prior assessment during the initial 42 months of treatment.

• 259 of the 260 men on TU showed improvement in AMSS scores.
• The improvement was observed at 6-12 monthly intervals across the treatment period.
• Analysis was performed using non-parametric statistics on a registry of men with adult-onset testosterone deficiency.
• The association with lower AMSS values was significant compared to both baseline and prior assessment.

In men not on testosterone undecanoate, AMSS values increased during 60 months of follow-up compared with baseline/prior assessment.

• 361 men were in the untreated group followed over 60 months.
• Only 1 man showed improvement in AMSS after 60 months without TU treatment.
• AMSS remained the same or worsened in 213 and 147 men, respectively, in the untreated group.
• This contrasts sharply with the treated group where 259 of 260 men showed improvement.

Baseline AMSS was inversely associated with change in AMSS (ΔAMSS) in men on testosterone undecanoate, with no other factors reaching significance.

• The inverse association between baseline AMSS and ΔAMSS in the TU-treated group had an R² = 0.97.
• No other factors besides baseline AMSS reached significance in predicting ΔAMSS in men on TU.
• Factors were established via linear and multiple regression analyses.

In men not on testosterone undecanoate, multiple factors were associated with ΔAMSS including baseline AMSS, age, serum total testosterone, waist circumference, and diastolic blood pressure.

• Baseline AMSS, age, serum total testosterone (TT), waist circumference (WC), and diastolic blood pressure (BP) were all associated with ΔAMSS in the untreated group.
• This contrasts with the treated group where only baseline AMSS was a significant predictor.
• Factors predicting ΔAMSS were established via linear and multiple regression analyses.

Baseline AMSS values inversely predicted ΔAMSS in both the treated and untreated groups.

• The inverse prediction of ΔAMSS by baseline AMSS was observed regardless of treatment status.
• In the TU group, R² = 0.97 for the inverse association between baseline AMSS and ΔAMSS.
• The registry included men with adult-onset testosterone deficiency analyzed at 6-12 monthly intervals over up to 60 months.