The effect of short-term consumption of Bifidobacterium bifidum on the gut microbiome of obese individuals.

Bifidobacterium bifidum probiotic supplementation positively affected specific bacterial species in the gut microbiome of obese individuals.

• Species positively affected included Bacteroides uniformis, Alistipes putredinis, Alistipes shahii, Dysosmobacter welbionis, and Gemmiger formicilis.
• The study used high-throughput sequencing on the DNBSEQ-G50 platform to characterize microbiome changes.
• The intervention was characterized as short-term consumption of the probiotic supplement.
• The study population consisted of individuals with obesity.

Gut microbiota dysbiosis is associated with obesity through disruption of energy consumption and metabolism.

• The authors identified gut microbiota dysbiosis as a mechanism that can lead to obesity by disrupting energy consumption and metabolism.
• Probiotic supplements were identified as a potential therapeutic option for improving intestinal homeostasis.
• This mechanistic background motivated the investigation of Bifidobacterium bifidum supplementation as a corrective intervention.

The identified bacterial species positively influenced by probiotic supplementation were suggested as potential candidates for treatment of gut microbiota dysbiosis in obese individuals.

• The authors suggested the potential use of Bacteroides uniformis, Alistipes putredinis, Alistipes shahii, Dysosmobacter welbionis, and Gemmiger formicilis in treating gut microbiota dysbiosis.
• The recommendation specifically targets dysbiosis associated with obesity.
• Microbiome analysis was conducted using high-throughput sequencing on the DNBSEQ-G50 platform.