ASCVD and a 10-year ASCVD risk score ≥5% are associated with the development of mental disorders including somatic symptoms, anxiety and insomnia, social dysfunction, and severe depression.
Key Findings
Results
Having ASCVD is associated with increased odds of somatic symptoms in a multivariate logistic regression model.
OR 1.138, 95% CI 1.069-1.212 for somatic symptoms
Analysis based on 1154 participants aged 25 to 70 enrolled in the Shiraz Heart Study cohort between 2016 and 2019
Mean age of participants was 44.25 ± 8.88 years; most were men (n = 621, 53.8%)
Mental health was evaluated using a 28-item general health questionnaire (GHQ-28)
Results
Having ASCVD is associated with increased odds of anxiety and insomnia.
OR 1.113, 95% CI 1.043-1.188 for anxiety and insomnia
Assessed via multiple logistic regression model with multivariate analysis
The 10-year ASCVD risk score was estimated using the ASCVD risk score estimator recommended by ACC/AHA guidelines
Results
Having ASCVD is associated with increased odds of severe depression.
OR 1.173, 95% CI 1.084-1.269 for severe depression
This finding was derived from a multiple logistic regression model
ASCVD was also associated with total general health scores (OR 1.053, 95% CI 1.027-1.079)
Results
Among participants without ASCVD, a 10-year ASCVD risk score ≥5% is associated with increased odds of somatic symptoms.
OR 1.126, 95% CI 1.035-1.224 for somatic symptoms
This analysis was restricted to participants without established ASCVD
A separate multiple logistic regression model was employed for this subgroup analysis
Results
Among participants without ASCVD, a 10-year ASCVD risk score ≥5% is associated with increased odds of anxiety and insomnia.
OR 1.117, 95% CI 1.031-1.211 for anxiety and insomnia
The risk score threshold of ≥5% was used to categorize elevated cardiovascular risk in this subgroup
Results
Among participants without ASCVD, a 10-year ASCVD risk score ≥5% is associated with increased odds of social dysfunction.
OR 1.121, 95% CI 1.034-1.215 for social dysfunction
Social dysfunction was one of four mental health subscales assessed by the GHQ-28
This association with social dysfunction was not observed in the ASCVD-present group in the reported results
Results
Among participants without ASCVD, a 10-year ASCVD risk score ≥5% is associated with increased odds of severe depression.
OR 1.195, 95% CI 1.078-1.324 for severe depression
10-year ASCVD risk score ≥5% was also associated with total general health scores (OR 1.068, 95% CI 1.035-1.102)
Study data were collected between 2016 and 2019 as part of the Shiraz Heart Study cohort
Zibaeenezhad M, Molazadeh J, Sayadi M, Bamooee Fard F, Rahmanian M, Bazrgar A, et al.. (2026). The effects of atherosclerotic cardiovascular disease and ten-year atherosclerotic cardiovascular disease risk score on mental health status.. Scientific reports. https://doi.org/10.1038/s41598-026-35737-6