Cardiovascular

The Evolving Burden of Stroke in China's 832 Poverty-Alleviated Counties (2019-2024): Nationwide Spatiotemporal Analysis.

TL;DR

Stroke prevalence in China's 832 poverty-alleviated counties surged markedly from 65.18 to 359.60 per 100,000 population (AAPC: +22.95%) from 2019 to 2024, with a worrying shift toward younger adults and persistent geographic clustering in northern provinces, demonstrating that economic advancement has not translated into proportionate health gains.

Key Findings

Stroke prevalence in China's 832 poverty-alleviated counties surged markedly from 65.18 to 359.60 per 100,000 population over the study period.

  • The overall Average Annual Percentage Change (AAPC) was +22.95%
  • The study covered 56.08 million residents across all 832 poverty-alleviated counties
  • Data were drawn from China's National Health Poverty Alleviation Dynamic Management System (NHPADMS)
  • The study period spanned from 2019 to 2024

The steepest increase in stroke prevalence occurred among younger adults aged 20 to 39 years.

  • The AAPC for adults aged 20 to 39 years was +35.63%, the highest among all age groups
  • This finding represents a worrying shift toward younger adults in the stroke burden
  • Trends were stratified by both age and sex in the analysis
  • Temporal trends were analyzed using Joinpoint regression to calculate annual percentage change and AAPC

Stroke incidence remained relatively stable from 2020 to 2023 but declined notably in 2024.

  • The pattern of incidence differed from the consistently rising prevalence trend
  • The notable decline in incidence was observed specifically in 2024
  • Joinpoint regression was used to analyze temporal trends in incidence as well as prevalence

The growth rate in stroke prevalence in poverty-alleviated regions far exceeded that in non-poverty-alleviated areas during 2019 to 2021.

  • Stroke prevalence growth rate in poverty-alleviated counties was +61.85% during 2019 to 2021
  • Stroke prevalence growth rate in non-poverty-alleviated areas was +3.82% during the same period
  • While absolute prevalence remained lower in poverty-alleviated counties, the growth rate differential was substantial
  • Comparative analysis used age-standardized prevalence rates referenced against the Global Burden of Disease standard population

Spatial analysis revealed persistent hyperendemic clusters of stroke burden in northern provinces of China.

  • The Hebei-Heilongjiang-Jilin-Inner Mongolia corridor was notably identified as a hyperendemic cluster
  • A significant north-south gradient in stroke burden was identified
  • Spatial clustering was assessed using Global and Local Moran's I statistics
  • The geographic clustering was described as persistent over the study period
  • The stroke burden became geographically polarized over the study period

The study covered a nationwide retrospective analysis of 56.08 million residents across all 832 poverty-alleviated counties in China.

  • Data source was China's National Health Poverty Alleviation Dynamic Management System (NHPADMS)
  • The study design was a nationwide retrospective analysis
  • Coverage included all 832 poverty-alleviated counties, representing the complete post-poverty-alleviation population
  • China's nationwide poverty alleviation was achieved by 2020, making this a key transitional period study

What This Means

This research examined stroke trends across all 832 counties in China that had previously been designated as impoverished and officially lifted out of poverty by 2020. Using health records from over 56 million residents collected between 2019 and 2024, the researchers tracked how often people were newly diagnosed with stroke (incidence) and how many people were living with stroke at any given time (prevalence). They also mapped where stroke cases were concentrated geographically and compared trends in these formerly poor counties to the rest of China. The study found that recorded stroke prevalence increased dramatically — more than fivefold — in these counties over the five-year period, rising from about 65 to nearly 360 cases per 100,000 people. Most alarmingly, the fastest growth was seen among adults aged 20 to 39, a group not traditionally associated with high stroke risk. The growth rate of stroke in these formerly impoverished areas was also far faster than in wealthier regions of China during the overlapping 2019–2021 period (+61.85% vs. +3.82%). Geographically, stroke cases were heavily clustered in northern China, particularly in a corridor spanning Hebei, Heilongjiang, Jilin, and Inner Mongolia provinces, and this clustering persisted throughout the study. This research suggests that achieving economic poverty alleviation does not automatically translate into better health outcomes for these populations. The dramatic rise in prevalence — particularly among young adults — and the persistent geographic concentration of stroke cases indicate that targeted public health interventions are urgently needed in these regions. The findings point to a need for stroke prevention and health promotion programs that are specifically designed to reach younger residents and communities in northern China, rather than applying a one-size-fits-all approach to post-poverty health policy.

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Citation

Chen M, Xia D, Li W, Wang J, Lv Z, Chen J, et al.. (2026). The Evolving Burden of Stroke in China's 832 Poverty-Alleviated Counties (2019-2024): Nationwide Spatiotemporal Analysis.. JMIR public health and surveillance. https://doi.org/10.2196/91487